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Old 01-06-2012
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Default Graft Vs Host

Ok, so stupid question here but need help. Why is that if I give say a person with low CD4+ (AID, SCID, MCHII absence....) a bone marrow transplant you do not see the G Vs. H disease? If I give the bone marrow wouldn't the marrow produce the lymphocytes even patient is immunocompromised and destroy the host tissues? Is this because in people who have low CD4+, whatever maybe causing it, will cause the new bone marrow not to produce lymphocytes (or make it but later change the T-cell pathway as with AIDs)?
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Old 01-06-2012
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I think if you use marrow from a HIV + patient there would be less GVHD chance. But anyhow you will never use marrow from a HIV patient. The vice versa will produce a GVHD. This is what i think.
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Old 01-06-2012
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I would guess that since there is a decrease in T helper cells, there is a decrease in certain cytokines that increase class I + II MHC expression (e.g. INF-y) .. Maybe the cytotoxic T cells from the donor won't have anything to attack?

I would assume that only T helper cells from the person they were derived from, can increase MHC expression in that same person??

Not sure about this one..
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Old 02-07-2012
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graft vs host disease is absent in ppl with MHC II defeciency because they lack the MHCII molecules against which grafted T cells can react.

not sure about whats the mechanism in SCID and AIDS
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