Factor V Leiden Pathophysiology! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-18-2010
Yallah's Avatar
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 81
Threads: 59
Thanked 172 Times in 43 Posts
Reputation: 182
Info Factor V Leiden Pathophysiology!

Can you help me guys. I was reading Kaplan notes and listening to the videos and did not really understand the issue with factor V Leiden.
Also, I've seen a question in Wikitestprep relating Factor V Leiden to Protein C or S!
If you have some info please share
Reply With Quote Quick reply to this message
The above post was thanked by:
wahaha007 (03-19-2010)



  #2  
Old 03-19-2010
USMLE Forums Veteran
 
Steps History: 1+CK+CS+3
Posts: 247
Threads: 61
Thanked 273 Times in 105 Posts
Reputation: 303
Default

1. Factor V is a coagulation factor that stimulate Prothrombin to convert to thrombin .. then activated thrombin causes more fibrin ... this fibrin is a fibrous protein involved in clotting of blood ... so causes hyper-coagulability like thrombosis , DVT , pulmonary embolism ....
2. Protein C is an is a Vit K dependent anticoagulant that inhibits the action of factor V with help of protein S .... thus protein C inhibits the hyper-coagulable state of factor V .....
3. Factor V Leiden is a variant of factor V where factor V is modified .. so protein C cannot inhibit modified factor V ... causes hyper-coagulable states .....
4. When there is protein C deficiency in some patients it cannot inhibit factor V ... causes hypercoagulable states ....
5. In Warfarin therapy it inhibits Vit k dependent factor 2 , 7, 9 , 10 , pr C , pr S .... Usually protein C level drops very fast than other coagulant factor ... as a result decrease natural anti coagulant protein C thus decrease inhibition on factor V causes hypercoagulable states ... which result in skin vascular thrombosis and causes skin necrosis .....
6. If there is factor V deficiency , there will be increase bleeding as ... no factor V to help factor XII to activate prothrombin ... thus decrease coagulation and leads bleeding ....
Reply With Quote Quick reply to this message
The above post was thanked by:
lee-usmle (03-19-2010), nikhil5001 (03-21-2010), shaheer (03-22-2010), shahra (03-19-2010), smile135 (03-28-2010), wahaha007 (03-19-2010), Yallah (03-19-2010)
  #3  
Old 03-19-2010
Yallah's Avatar
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 81
Threads: 59
Thanked 172 Times in 43 Posts
Reputation: 182
Thumbs Up Awesome

Thank FSUSTC,
That's awesome explanation
I'll never forget it
Reply With Quote Quick reply to this message
  #4  
Old 04-20-2010
USMLE Forums Scout
 
Steps History: 1 + CK
Posts: 32
Threads: 4
Thanked 12 Times in 8 Posts
Reputation: 22
Default

Quote:
Originally Posted by FSUSTC View Post
1. Factor V is a coagulation factor that stimulate Prothrombin to convert to thrombin .. then activated thrombin causes more fibrin ... this fibrin is a fibrous protein involved in clotting of blood ... so causes hyper-coagulability like thrombosis , DVT , pulmonary embolism ....
2. Protein C is an is a Vit K dependent anticoagulant that inhibits the action of factor V with help of protein S .... thus protein C inhibits the hyper-coagulable state of factor V .....
3. Factor V Leiden is a variant of factor V where factor V is modified .. so protein C cannot inhibit modified factor V ... causes hyper-coagulable states .....
4. When there is protein C deficiency in some patients it cannot inhibit factor V ... causes hypercoagulable states ....
5. In Warfarin therapy it inhibits Vit k dependent factor 2 , 7, 9 , 10 , pr C , pr S .... Usually protein C level drops very fast than other coagulant factor ... as a result decrease natural anti coagulant protein C thus decrease inhibition on factor V causes hypercoagulable states ... which result in skin vascular thrombosis and causes skin necrosis .....
6. If there is factor V deficiency , there will be increase bleeding as ... no factor V to help factor XII to activate prothrombin ... thus decrease coagulation and leads bleeding ....





this is the best explanation I heard so far for this mutation. Very nice !!
Reply With Quote Quick reply to this message



Reply

Tags
Hematology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Pathophysiology Score not going up AndyG83 USMLE Step 1 Forum 1 08-01-2016 10:56 AM
Pathophysiology of AV fistula svmle USMLE Step 2 CK Forum 1 05-19-2012 04:36 PM
Pathophysiology of TIA? kemoo USMLE Step 3 Forum 1 04-15-2012 07:16 PM
How do I improve my pathophysiology 1128 USMLE Step 1 Forum 8 11-22-2011 11:43 AM
What is PathoPhysiology and where i study it from? MedicalDR14 USMLE Step 1 Forum 3 11-22-2010 02:15 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)