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Old 01-06-2012
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Bones Pathogenesis of Osteoarthritis; Role of cytokines

In osteoarthritis pathogenesis of damage is cytokine mediated injury...but OA is non inflamatory condition so where cytokines come form?

Can you please explain this concept for me?
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Old 01-07-2012
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what i know is osteoarthritis is degenerative disease in weight bearing joints.

simply aging and wear & tear leads to destruction of the articular cartilage. joint space narrowing occurs and bone comes in contact with bone.the destructive components of cartilage and bone released into the joint cavity may induce some inflammation.

but the disease is not cytokine induced and its not autoimmune.its a degenerative disease
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But Goljan mentions cytokine mediated injury!! that's what am confused about
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Old 01-07-2012
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Quote:
Originally Posted by doxorubicin View Post
in osteoarthritis pathogenesis of damage is cytokine mediated injury...bt oa is non inflamatory condition so wer cytokines come 4m???

can ny1 explian tis concept..thx
The pathogenesis of osteoarthritis is very complicated. It is a typical multifactorial disease (environment + genetics).

When we say non-inflammatory with regards to osteoarthritis we mean that the primary pathogenesis is an intrinsic dysfunction of chondrocytes rather than due to infiltration of immune cells (although these may still be seen in osteoarthritis).

Inflammatory mediators are not exclusively secreted by immune cells. In the case of osteoarthritis, chondrocytes (in early stages) proliferate and secrete inflammatory mediators among other things to alter architecture of the cartilagenous matrix.
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So degenerative and cytokine mediated but not considered under inflamatory that's what it means right?
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Quote:
Originally Posted by doxorubicin View Post
so degenratv n ck mediated bt nt considered under inflamatory tats wat it means rt?
Pretty much it seems. Not considered inflammatory because the primary pathogenesis doesn't seem to be mass infiltration of inflammatory cells (but they can still play a role).
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