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  #1  
Old 01-08-2012
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Biochemistry Which disease caused by Enzyme Denaturation

Which of the following ailments, seen by an emergency room Dr, is most likely caused by enzyme denaturation?
(A) A 34 year old man diagnosed with a gastrinoma complaining of diarrhea for 2 weeks
(B) A 58 year old man with chest pain and shortness of breath with increased activity
(C) an 18 year old boy presenting with a sore throat and fever of 101oF; he has a small minimally tender anterior cervical lymph nodes and a red pharynx
(D) an 18 month old boy with a 4 day history of symptoms of an upper repiratory infection presenting with fever, irritability and pulling at his left ear for the past 24hrs
(E) A 48 year old woman complaining of knee pain after twisting her leg playing tennis

Answer with reasoning plz.
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  #2  
Old 01-08-2012
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Default A....

I think is like this:

2 weeks of diarrhea ---> HCO3 depletion ---> acidosis ---> enzyme denaturalization ---> death
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  #3  
Old 01-08-2012
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I think C seems C.diphtheria. Toxin leading to inhibition of elongation factor involved in protein synthesis.
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Old 01-08-2012
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I would have gone with C, but does C diptheria present with enlarged LN?
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Old 01-08-2012
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Is it zollinger ellison's causing denaturation of enzymes leading to malabsorptive diarrhea? Seems kinda far fetched, though. :: confused::

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Old 01-08-2012
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I ll go with D...but it's a guess
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Old 01-08-2012
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Quote:
Originally Posted by smanthrav View Post
Is it zollinger ellison's causing denaturation of enzymes leading to malabsorptive diarrhea? Seems kinda far fetched, though. :: confused::
Yeah you are right... I have not clue.
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Old 01-09-2012
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B, increased activity leading to a heat stroke leading to a CV collapse
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Old 01-09-2012
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Idea!

(B) A 58 year old man with chest pain and shortness of breath with increased activity

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  #10  
Old 01-09-2012
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Either A or C.

Enzymes can be denatured by high temperature or extremes of PH.
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Old 01-09-2012
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i would go with c
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Old 01-10-2012
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Default Dental Clinic near Sarjapur road

Enzyme activity can be affected by other molecules. Many drugs and poison are enzyme inhibitors.

Good Dental Clinic in Sarjapur Road
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Old 01-11-2012
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Default alpha 1 antitrypsin?

what about alpha antitrypsin?
Quote:
Originally Posted by patho2012 View Post
Which of the following ailments, seen by an emergency room Dr, is most likely caused by enzyme denaturation?
(A) A 34 year old man diagnosed with a gastrinoma complaining of diarrhea for 2 weeks
(B) A 58 year old man with chest pain and shortness of breath with increased activity
(C) an 18 year old boy presenting with a sore throat and fever of 101oF; he has a small minimally tender anterior cervical lymph nodes and a red pharynx
(D) an 18 month old boy with a 4 day history of symptoms of an upper repiratory infection presenting with fever, irritability and pulling at his left ear for the past 24hrs
(E) A 48 year old woman complaining of knee pain after twisting her leg playing tennis

Answer with reasoning plz.
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  #14  
Old 01-11-2012
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i think u have to think about it like this - what causes enzyme to denature ? - mcc is heat . so that guy with the 101oF is very high. so my guess would be
C. ; )
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Old 01-29-2012
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So what's the answer then

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  #16  
Old 01-29-2012
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B. Patient with MI
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  #17  
Old 01-30-2012
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for enzyme denaturation to occur, its pH or temp

diarrhea can lead to acidosis so thats possible however C is out of the question because for temperature to cause denaturation it needs to be 106.

B sounds like an MI and thats def denaturation
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  #18  
Old 01-30-2012
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Ans D ..... looks like cystic fibrosis .......
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Old 01-30-2012
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Default

Good question.
I do not know the answer, frankly...

But from the options present, I'd make a guess for the option "A".
I would think that gastrinoma, like the one from Zollinger-Elison would produce high amounts of gastrin and somehow maybe throgh increased HCL production denaturate some GI enzymes leading to diarrhea
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  #20  
Old 01-30-2012
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whats the right answer then??
n whats the source of the question?
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  #21  
Old 01-30-2012
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the correct answer is A


check out point number 6 in RED in the article below

http://www.scribd.com/doc/6902359/GI...and-Gastrinoma


and check this out
http://books.google.com/books?id=zoN...uLbFE&hl=en&sa
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