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Old 01-14-2012
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Drug Why Epinephrine in local anesthesia

Enhancement of spinal anesthesia by the presence of epinephrine in local anesthetics: Reason(s) --

A) increased substance P release
B) increased dorsal horn neuronal activity
C) decreased local neuronal uptake
D) none of the above
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Old 01-14-2012
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not sure if i understand the question entirely but i'll say... C? (either C or D)
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Old 01-14-2012
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Answer is D , as its not related to substance P release or Increase in dorsal horn neuronal activity .. and it increases local neuronal uptake doesnot decrease local neuronal uptake .
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Old 01-14-2012
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Quote:
Originally Posted by Hitman View Post
Answer is D , as its not related to substance P release or Increase in dorsal horn neuronal activity .. and it increases local neuronal uptake doesnot decrease local neuronal uptake .
yeah seems answer D is correct......but how does it increases local neuronal uptake????????

Addition of epinephrine is done to reduce the uptake of anesthetic by blood vessels since EPI causes vasoconstriction!!!!!!
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Quote:
Originally Posted by anomali View Post
yeah seems answer D is correct......but how does it increases local neuronal uptake????????

Addition of epinephrine is done to reduce the uptake of anesthetic by blood vessels since EPI causes vasoconstriction!!!!!!
Epi causes vasoconstriction that allows LA to stay localized , prevents systemic toxicity and thus more neuronal uptake as more conc of LA available for neuron receptors ..
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Old 01-15-2012
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D) none of the above
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