Causes of Macrondoular Cirrhosis - USMLE Forums
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Old 01-15-2012
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Liver Causes of Macrondoular Cirrhosis

Which of the following conditions results in macronodular (> 3 mm) cirrhosis rather than micronodular cirrhosis?
A) Hereditary Hemochromatosis
B) Alcoholic Cirrhosis
C) Postnecrotic Hepatitis B
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Old 01-15-2012
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Post necrotic Hep B infection
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Postnecrotic Hepatitis macronodular
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Old 02-10-2012
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need explanation
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postnectrotic hep b leads to macronodular due to large damage
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Old 02-11-2012
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Default Dr. Evergreen, please post your choice

I came across several of your questions; they are great but they need your personal answer.

Thanks and keep it coming.
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Old 02-11-2012
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Quote:
Originally Posted by slime66 View Post
I came across several of your questions; they are great but they need your personal answer.

Thanks and keep it coming.

Many thanks Dr. Slim66.

The answer is C. Viral hepatitis (B or C) is the most common cause of macronodular cirrhosis.
Wilson's disease and Alpha-1-antitrypsin deficiency can also cause a macronodular cirrhosis.

The most common casue for micronodular cirrhosis is chronic alcoholism. Micronodular cirrhosis may also be seen with Wilson's disease, primary biliary cirrhosis, and hemochromatosis.
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Old 02-11-2012
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Default It does make sense.

& thank you.
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Old 02-15-2012
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Default hi ...just wanted to add

to add on to the above answer... one of the path guys(kaplan videos) explains that alcohol can cause both micro and macronidular cirrhosis:-
if alcohol is consumed in amounts more than 14-21 units per week (i.e., exceeding the limit on a regular /daily basis) it causes micronodular cirrhosis over time...
but when binged every once in every 2-4 weeks for a long time...(i.e.,the ones who come to the hospital for acute pancreatitis/alcoholic gastritis/alcohol intoxication/recurrent mallory weiss tears) tend to have macronodular cirrhosis over the years ,as each time a larger damage occurs to the liver and hence larger regenerating nodules.

but doublessly postnecrotic cirrhosis is macronodular...(a concept mentioned flatly in wikipedia as well)
hope i havent confused anyone.
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