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  #1  
Old 01-16-2012
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Kidney The cause of Hyperlipidemia in Nephrotic syndrome

Which of the following is not related to hyperlipidemia in nephrotic syndrome?
A) Increased production of lipoproteins by the liver
B) Increased protein loss in the urine
C) Decreased levels of lipoprotein lipase
D) Increased levels of lipoprotein lipase
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  #2  
Old 01-16-2012
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it is D the answer
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Old 01-16-2012
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Quote:
Originally Posted by Evergreen View Post
Which of the following is not related to hyperlipidemia in nephrotic syndrome?
A) Increased production of lipoproteins by the liver
B) Increased protein loss in the urine
C) Decreased levels of lipoprotein lipase
D) Increased levels of lipoprotein lipase

Ans : C ..... decrease lipoprotein lipase ....
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Old 01-16-2012
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Default d

i think its D
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Old 01-17-2012
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not sure whether it's C or D.. does lipoprotein lipase have a role to play in nephrotic syndrome?
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Old 01-17-2012
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C

In nephrotic syndrome, on the impairment of peripheral lipid utilization is primarily the impact of reduced activity of enzymes responsible for it.
The causes of decline (up to 60%) activity of lipoprotein lipase, both in plasma and in endotheliums and other tissues may be: an increase in FFA levels, increased cholesterol levels, loss with the urine activators or an imbalance between the cofactor (ApoCII) and its inhibitor (ApoCIII), in favor of the last one.
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Old 01-17-2012
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C i guess........decresed levels pf LPL would reduce the breakdown of TG and subsequently increase lipid levels in the blood!!!!!!!!!
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Old 01-17-2012
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Quote:
Originally Posted by pambam View Post
C

In nephrotic syndrome, on the impairment of peripheral lipid utilization is primarily the impact of reduced activity of enzymes responsible for it.
The causes of decline (up to 60%) activity of lipoprotein lipase, both in plasma and in endotheliums and other tissues may be: an increase in FFA levels, increased cholesterol levels, loss with the urine activators or an imbalance between the cofactor (ApoCII) and its inhibitor (ApoCIII), in favor of the last one.

So decreased lipoprotein lipase is the consequence of nephrotic syndrome? So the ans should be D???
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Old 01-17-2012
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sure!!! thats right!!! NOT RELATED!!! the answer is D!!!

decrease is the cause!!! sorry my mistake!!!

i remember this in a easy way: if you piss with smth what active your lipase, as a result of this you can't cutting your fat, so you have it more and more===>hiperlipidemia.

correct me if i'm wrong
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Old 01-17-2012
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Hyperlipidemia in Nephrotic syndrome is due to hypoalbuminemia , liver tries to increase production of proteins = lipoproteins thus increase in LDL , VLDL , TG , Cholestrol and low levels of Lipoprotein lipase

ans is C .... from U world ....
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Old 01-17-2012
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Correct Answer

Answer is D. Pay attention to "not related" in the question.

Hyperlipidemia in nephrotic syndrome is caused by two factors:
  • Hypoproteinemia stimulates protein synthesis in the liver, resulting in the overproduction of lipoproteins.
  • Lipid catabolism is decreased due to lower levels of lipoprotein lipase, the main enzyme involved in lipoprotein breakdown.
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