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Old 01-21-2012
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Blood Favorable mutation in Leukemia

A 3-year-old child has had five episodes of febrile illness in the past 3 months. Her pediatrician sends a blood sample for hematologic analysis, which reveals a white blood cell count of 45,000/mm3, an erythrocyte count of 100,000/mm3, and a platelet count of 42,000/mm3. Many blast cells are seen in the smear. A sample is sent for flow cytometry, which is able to characterize the blast cells as marking with CD19, CD79, and TdT. A sample sent for genetic analysis demonstrates a common mutation that confers a good prognosis. This mutation most likely involves which of the following?
(A) t(1;19)
(B) t(4;11)
(C) t(9;22)
(D) t(11;29)
(E) t(12;21)
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Old 01-21-2012
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E)under 17,TdT marker for pre B and T cells,CD 19--- t(12;21)
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Old 01-21-2012
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ans . E ........
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Old 01-21-2012
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E

http://awurl.com/VLNrJUFIW
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Old 01-21-2012
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sorry guys,
could you explain further?
what is 12:21? ALL?
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Old 01-22-2012
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The answer is E.

This child has precursor B-cell acute lymphoblastic leukemia (B-ALL). The B-cell lineage can be indicated by antigens expressed either in the cytoplasm (CD79 or IgM) or on the surface membrane (CD19 or CD20) of the leukemic cells. The precursor nature of the blast cells can be demonstrated with further marker studies, including positivity for TdT (a nuclear enzyme) or surface markers CD10 and CD34. The most common genetic abnormality seen in childhood ALL involves the TEL-AML1 fusion gene, which is created by the translocation t(12;21). This abnormality occurs only in B-precursor ALL and confers an excellent prognosis. The other translocations listed have also been observed in precursor B-ALL.
t(1;19) (choice A) occurs in 5% of precursor B-ALL cases and has a roughly neutral prognosis.
t(4;11) (choice B)and t(11;29) (choice D) are translocations involving 11q23,which codes for the MLL gene product, and convey a poor prognosis. t(9;22) (choice C)involves BCR-ABL and conveys a poor prognosis.
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Old 01-22-2012
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t(11;29).......i guess the no's here represent the chromosome number????

whats this 29????? we have 23 pairs right? dint get this!!!!!!! Am i missing any link?
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Old 01-22-2012
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Its a typo i guess
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