Steroid Hormone Receptors HY! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-26-2010
ayash's Avatar
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 88
Threads: 28
Thanked 116 Times in 25 Posts
Reputation: 126
Thumbs Up Steroid Hormone Receptors HY!

Hello forum members,

Just thought I would share these HY notes with you all.

Good Luck!
Attached Files
File Type: pdf Steroid Hormone Receptors.pdf (124.5 KB)
Reply With Quote Quick reply to this message
The above post was thanked by:
ahmedadamos (07-01-2013), aktorque (01-17-2011), amnios (04-28-2010), ashishkabir (03-27-2010), ath.pantelis (03-27-2010), bronchiole (03-27-2010), cuteumder (10-05-2012), doc swati kaluva (10-25-2012), doctorF (04-12-2010), dr.Zh (09-26-2012), drortho (02-09-2012), GNND85 (03-26-2010), keyur (09-20-2012), Mahony87 (01-24-2011), ms.med (01-19-2011), orfie25 (07-14-2011), ozchou (04-25-2011), pass7 (09-02-2011), prabin (11-27-2012), saint (04-12-2010), sang63 (01-30-2016), Seetal (04-12-2010), shaan175 (07-15-2012), silverwyvern4 (06-14-2013), slime66 (12-17-2011), smacker (09-19-2012), step1an (01-20-2011), step1success (09-19-2012), Taiwan_Guy (05-16-2011), walt65 (11-20-2014), wimzie (01-24-2011)



  #2  
Old 03-26-2010
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 82
Threads: 4
Thanked 80 Times in 30 Posts
Reputation: 90
Default

This is very nice, thank you!
Reply With Quote Quick reply to this message
  #3  
Old 03-27-2010
USMLE Forums Scout
 
Steps History: Not yet
Posts: 69
Threads: 16
Thanked 46 Times in 21 Posts
Reputation: 84
Send a message via Yahoo to mosallam Send a message via Skype™ to mosallam
Default

txx u dr ayash , very systematized
Reply With Quote Quick reply to this message
 
  #4  
Old 04-12-2010
USMLE Forums Scout
 
Steps History: Not yet
Posts: 32
Threads: 2
Thanked 35 Times in 11 Posts
Reputation: 55
Default

thks alot dear for this great help
Reply With Quote Quick reply to this message
  #5  
Old 04-12-2010
doctorF's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 316
Threads: 68
Thanked 407 Times in 110 Posts
Reputation: 427
Default

o this is something that really troubles me alot... swear!!! thanks ayash
Reply With Quote Quick reply to this message
  #6  
Old 04-13-2010
Seetal's Avatar
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 919
Threads: 134
Thanked 1,310 Times in 364 Posts
Reputation: 1333
Send a message via MSN to Seetal
Default

thanks ayash that was really helpful!!
Reply With Quote Quick reply to this message
  #7  
Old 01-17-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

Quote:
Originally Posted by ayash View Post
Hello forum members,

Just thought I would share these HY notes with you all.

Good Luck!
ARE you sure about thyroid and vitD receptors being inside nucleus? are not they in cytoplasm? just wondering! different sources different inputs
Reply With Quote Quick reply to this message
  #8  
Old 01-19-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

Quote:
Originally Posted by hana View Post
ARE you sure about thyroid and vitD receptors being inside nucleus? are not they in cytoplasm? just wondering! different sources different inputs
ok i just read that thyroid hormones receptors are located in nucleus but still not sure about vit.D.
ANYONE? ANY IDEAS?
Reply With Quote Quick reply to this message
  #9  
Old 01-19-2011
Hokolesqua's Avatar
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 262
Threads: 6
Thanked 370 Times in 154 Posts
Reputation: 380
Default

Quote:
Originally Posted by hana View Post
ok i just read that thyroid hormones receptors are located in nucleus but still not sure about vit.D.
ANYONE? ANY IDEAS?
Vitamin D is fat soluble and therefore it must be able to slip through the cell membrane and nuclear membrane and exerts its action there.
Reply With Quote Quick reply to this message
  #10  
Old 01-20-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

Quote:
Originally Posted by Hokolesqua View Post
Vitamin D is fat soluble and therefore it must be able to slip through the cell membrane and nuclear membrane and exerts its action there.
Not necessary. we are talking about whether receptor is in cytoplasm or in nucleus. as you know steroid hormones -glucocorticoids, testosteron,..-are all lipid soluble but their receptor are located in cytoplasm. please correct me if i am missing something here.
Reply With Quote Quick reply to this message
  #11  
Old 01-21-2011
Hokolesqua's Avatar
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 262
Threads: 6
Thanked 370 Times in 154 Posts
Reputation: 380
Default

Quote:
Originally Posted by hana View Post
Not necessary. we are talking about whether receptor is in cytoplasm or in nucleus. as you know steroid hormones -glucocorticoids, testosteron,..-are all lipid soluble but their receptor are located in cytoplasm. please correct me if i am missing something here.
Steroid hormone receptors are located in the nucleus not in the cytoplasm.
When a substance is lipid soluble, there's no need for cell surface or cytoplasmic receptor as it can diffuse in.
To reaffirm for you the location of Vitamin D receptor please read this Wikipedia article http://en.wikipedia.org/wiki/Calcitriol_receptor
Reply With Quote Quick reply to this message
  #12  
Old 01-22-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

Quote:
Originally Posted by Hokolesqua View Post
Steroid hormone receptors are located in the nucleus not in the cytoplasm.
When a substance is lipid soluble, there's no need for cell surface or cytoplasmic receptor as it can diffuse in.
To reaffirm for you the location of Vitamin D receptor please read this Wikipedia article http://en.wikipedia.org/wiki/Calcitriol_receptor
you can not always trust wikipedia..

i am not sure about vitD RECEPTOR but i am pretty sure steroid receptors are in cytoplasmn when hormone binds receptor then H-R complex is dislocated into nucleus and seat on HRE.
Reply With Quote Quick reply to this message
  #13  
Old 01-22-2011
Hokolesqua's Avatar
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 262
Threads: 6
Thanked 370 Times in 154 Posts
Reputation: 380
Default Trust me on this one

Quote:
Originally Posted by hana View Post
I am pretty sure steroid receptors are in cytoplasmn when hormone binds receptor then H-R complex is dislocated into nucleus and seat on HRE.
What you said, means that the ultimate receptor for steroids is in the nucleus!
The GRE (Glucocorticoid response element) is in the DNA. This is the ultimate receptor for all steroid hormones.
The HRE complex is a temporary messenger, the ultimate receptor is in the nucleas. This is well known and is not debatable. In fact, it's a common question in the USMLE where they ask you about the location of steroid hormone receptor and you have to choose the nucleus.
If you don't trust Wikipedia Here's a diagram from Cell and Molecular Biology: Concepts and Experiments by Gerald Karp


And for vitamin D, here's a diagram from Vitamin D: Physiology, Molecular Biology, and Clinical Applications (Nutrition and Health)
Reply With Quote Quick reply to this message
The above post was thanked by:
Mondoshawan (01-22-2011), Sabio (01-22-2011)
  #14  
Old 01-22-2011
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 590
Threads: 31
Thanked 1,229 Times in 411 Posts
Reputation: 1253
Default I wonder how the question would be phrased?

Whether cytoplasmic (like cortisol in Hokolesqua's first picture) or nuclear (like Vit D in the second picture), the principle still applies, as both regions are separated from the circulation by a lipid membrane. A hydrophilic molecule would have a receptor on the cell membrane; a lipophilic one past the cell membrane. So Hana's question about cytoplasm v. nucleus was valid. But, as Hokolesqua said, there is no second messenger. I'm interested to know how the question would be phrased, in the case of, say cortisol. It meets the GR in the cytoplasm and travels with two of them into the nucleus, where the complex binds to the response element. Hmm...

Looks like Vit D was answered anyway!
Reply With Quote Quick reply to this message
  #15  
Old 01-22-2011
dr z's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 136
Threads: 34
Thanked 349 Times in 89 Posts
Reputation: 369
Question plz clarify!

The attached PDF states nuclear receptor for T3/T4 & Vit A & Vit D
but FA 2011 states Vit D as cytosolic
can anyone tell which one is correct?
Reply With Quote Quick reply to this message



  #16  
Old 01-23-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

Quote:
Originally Posted by dr z View Post
The attached pdf states
nuclear receptor for T3/T4 & VitA & Vit D
but FA 2011 states Vit D as cytosolic
can anyone tell which one is correct?
that is why i asked about vitD, different sources different info..
huuuuum, may be it is just not high yeild? whether in nucleus or cytoplasm.
Reply With Quote Quick reply to this message
  #17  
Old 01-23-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 82
Threads: 22
Thanked 33 Times in 14 Posts
Reputation: 36
Default

@hokolesqua;
if cortisol does not seat on it is receptor at first place in cytoplasm ,there is no way it can access into nucleus.
the target is nucleus-gene expression modification-but receptor cytoplasm
and i just read this q on UW yesterday it clearly said ;MOST steroid receptors are cytoplasmic " .
i would choose cytoplasm in exam
btw,thanks for nice photos you posted
Reply With Quote Quick reply to this message
  #18  
Old 01-23-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 1
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default

thank you bro
Reply With Quote Quick reply to this message
  #19  
Old 09-19-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 96
Threads: 15
Thanked 19 Times in 18 Posts
Reputation: 29
Default

i thought thyroid hormones are nuclear and so is vit a n d confusion
Reply With Quote Quick reply to this message
The above post was thanked by:
step1success (09-19-2012)
  #20  
Old 09-26-2012
USMLE Forums Newbie
 
Steps History: CK Only
Posts: 7
Threads: 2
Thanked 1 Time in 1 Post
Reputation: 11
Default

thanks alot
Reply With Quote Quick reply to this message



Reply

Tags
Figures-, Molecular-Biology-, PDF-Attachments

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Beta and Alpha Receptors effects on Insulin and Renin rasheed USMLE Step 1 Mnemonics 6 11-23-2015 02:37 AM
NMDA receptors DrSeddik USMLE Step 1 Forum 9 12-06-2012 09:31 PM
Hormone Receptors lee-usmle USMLE Step 1 Bits & Pieces 1 08-05-2011 07:28 PM
G Protein Coupled Receptors Table rasheed USMLE Step 1 Bits & Pieces 1 05-17-2010 08:38 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)