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  #1  
Old 02-02-2012
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Microscope Anaplastic tumor cells infiltrating the epidermis

A 65-year-old woman presents with a pruritic red, crusted, sharply demarcated map-like lesion involving a large portion of her labia majora. Histologic sections from this lesion reveal individual anaplastic tumor cells infiltrating the epidermis. Distinctive clear spaces are noted between these anaplastic cells and the surrounding normal epithelial cells. These malignant cells stain positively for mucin and negatively with S100. Which of the following is the most likely diagnosis?
A. Clear cell adenocarcinoma
B. Malignant melanoma
C. Extramammary Paget's disease
D. Sarcoma botryoides
E. Squamous cell carcinoma
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Old 02-02-2012
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adenocarcinoma?? mucin +ve


how wud pagets manifest?
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Old 02-02-2012
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it is A adeno ca
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Old 02-02-2012
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ans ....... A........
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Old 02-03-2012
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C....pagets
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Old 02-03-2012
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Quote:
Originally Posted by mbbs2010 View Post
how wud pagets manifest?
nonpruritic, red, crusted lesion.

Large, malignant epithelial cells that are disposed singly or in clusters throughout the epidermis.

Cells are mucin positive indicating that they are adenocarcinoma cells that derive from intraepidermal stem cells.
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Old 02-03-2012
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Pagets disease I guess....the crusted lesions and mucin staining(PAS) give it away.

Sent from my HTC Inspire 4G
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Old 02-03-2012
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Extra mammary paget lesion
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