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Old 02-04-2012
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Syringe Isotope Switching for Vaccine Development

4 year old boy is brought to the ER in extreme respiratory distress with a temperature of 49.9. He is drooling and has difficulty swallowing and inspiratory stridor is noted on physical examination. The vaccine that would have protected against this condition contains which of the following substances in order to stiumulate isotype switching??
a- diphteria toxoid
b- endotoxin
c- hemagglutinin
d- mycolic acid
e- polyribitol phosphate
f- protein A
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Old 02-04-2012
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Ans ...... A.........
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Old 02-04-2012
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Hemagluttinin i guess...not sure
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Old 02-04-2012
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Default Its A....

The child suffers from epiglottitis caused by Haemophilus influenze....its vaccine is polysaccharide capsule which is conjugated with a protein like tetanus or diptheria toxoid for T cell response....!!!!!!!!!!!
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Old 02-04-2012
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A

its H.influenza infection

conjugated with Diphteria to administer
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Old 02-05-2012
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Default D

to improve the reaction?
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Old 02-05-2012
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T cell response is needed for memory and polysach antigen does not confer it. therefore conjugation with Diphtheria toxoid will provide the necessary component to elicit a T cell response>>>class switching and memory.
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Old 02-05-2012
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A Toxoid
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Old 02-06-2012
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THE ANSWER IS A.. Diptheria Toxoid. Even though H.Influenza type B has polysaccharide capsule (type B capsule of polyribitol phosphate) it also needs Diphtehria toxoid for the vaccine. Capsular polysacharide serves as a hapten to which B lymphocytes will respond producing antibody. In Hib vaccine, the capuslar polysaccharide of the organism is covalently coupled toa protein carrier like diphtheria toxoid, thereby makign it a T cell dependant vaccine and stimulating B cells to produce isotype switching..
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