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Old 02-08-2012
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why is thiamine given in folate deficiency?
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Old 02-08-2012
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B1 or thiamine can be given to decrease numbness, weakness and tingling of fingers and toes.......in apatient who has folic acid or wat you called foliate defiency............v simple
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Originally Posted by jaik View Post
B1 or thiamine can be given to decrease numbness, weakness and tingling of fingers and toes.......in apatient who has folic acid or wat you called foliate defiency............v simple
folic acid deficiency leads to weakness and tingling of fingers and toes ????
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Old 02-08-2012
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i had read an explanation some time back that in folate deficiency there is dTMP ( de novo synthesis).
however dTM( salvage pathway) using thymidine kinase can compensate so thiamine is used.
had written it in my fa long time back ,some part of i can never understand.
can any1 explain what does this mean?
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Old 02-08-2012
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open to page 365 and page 68 FA 2011 u will understand .

i couldn't get your question earlier,u made a mistake actually

CH2-THF is the methyl donor for Reaction dUMP------dTMP
folate deficiency results is less dTMP so less DNA synthesis .

if u supplement thymidine then folate is not needed.
important drugs act here methotrexate and 5-flourouracil

and thymidine is not same as thiamine .pls there is a world of difference between them .one is vitamin ,the other is a pyramidine Base
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Originally Posted by jaik View Post
B1 or thiamine can be given to decrease numbness, weakness and tingling of fingers and toes.......in apatient who has folic acid or wat you called foliate defiency............v simple
PLEASE can u explain more .because i feel u are mistaken somewhere . . . .
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open to page 365 and page 68 FA 2011 u will understand .

i couldn't get your question earlier,u made a mistake actually

CH2-THF is the methyl donor for Reaction dUMP------dTMP
folate deficiency results is less dTMP so less DNA synthesis .

if u supplement thymidine then folate is not needed.
important drugs act here methotrexate and 5-flourouracil

and thymidine is not same as thiamine .pls there is a world of difference between them .one is vitamin ,the other is a pyramidine Base
yeah i got it ! how could i read thymidine thiamine!!!!! damn!
apologies for the confusion..
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