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  #1  
Old 02-10-2012
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Molecular Insulin Receptor Signaling Pathway

Which of the following is not correct regarding the insulin-receptor signaling pathway?

A) Phosphorylation of insulin receptor substrate causes translocation of GLUT-4 to membrane in adipose and muscles via activation of PI-3 kinase.
B) Autophosphorylation of insulin receptor may ultimately cause dephosphorylation of some intracellular enzymes.
C) Proteins with SH2 domain to bind to the phosphotyrosine residues on phosphorylated insulin-receptor substrate (IRS-1) and cause stimulation of p21ras.
D) Insulin binding to its receptor causes phosphorylation of several proteins via Gs protein-coupled tyrosine kinase.
E) Autophosphorylation of tyrosine kinase associated with the cytoplasmic domain of insulin binding receptor is not related to adenylyl cyclase.
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Old 02-10-2012
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answer is E
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Old 02-11-2012
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Seems to me the right answer is E)
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Old 02-11-2012
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We need to find the false one so i feel the ans is D , tyrosine receptor is not a G protein receptor ....
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Old 02-11-2012
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Originally Posted by Hitman View Post
We need to find the false one so i feel the ans is D , tyrosine receptor is not a G protein receptor ....
Same here... I go for D
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Old 02-11-2012
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i think its D.
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Old 02-11-2012
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Default I think it is E

E is my choice
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Old 02-11-2012
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Thumbs Up Answer is D.

Quote:
Originally Posted by slime66 View Post
E is my choice
Answer is D. because insulin signaling is not mediated by Gs protein signaling. It is via tyrosine kinase receptor signaling which is not associated with G-coupled receptors/adenylyl cylcase.

Other answers are correct.
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Old 02-11-2012
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Default Thanks!

For your intricate explanations.
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Originally Posted by Evergreen View Post
Which of the following is not correct regarding the insulin-receptor signaling pathway?

A) Phosphorylation of insulin receptor substrate causes translocation of GLUT-4 to membrane in adipose and muscles via activation of PI-3 kinase.
B) Autophosphorylation of insulin receptor may ultimately cause dephosphorylation of some intracellular enzymes.
C) Proteins with SH2 domain to bind to the phosphotyrosine residues on phosphorylated insulin-receptor substrate (IRS-1) and cause stimulation of p21ras.
D) Insulin binding to its receptor causes phosphorylation of several proteins via Gs protein-coupled tyrosine kinase.
E) Autophosphorylation of tyrosine kinase associated with the cytoplasmic domain of insulin binding receptor is not related to adenylyl cyclase.
sure of the answer,..
its D

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