Q. change in RBC count in alpha & B- thalassemia? - USMLE Forums
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Old 09-15-2015
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Default Q. change in RBC count in alpha & B- thalassemia?

Q.In both Goljan & pathoma, there is mention of increased RBC count only in B-thalassemia minor and alpha-thalassemia when 2 genes are deleted. Won't there by increased RBC count in B-thalassema major and if 3 or 4 genes are deleted in alpha-thalassemia? Why RBC count is increased in some conditions (as mentioned) and not in others ?.Pls share your knowledge and understanding on this.Thanks
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Old 09-16-2015
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i think the rbcs are made by the bone marrow for compensation
in beta thalessemia there is an obvious disease of rbcs so that they are phagocytosed by the spleen than the other two...maybe thats y u see a decreased rbc in beta thal major
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Old 09-16-2015
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Thanks smita . But, if increase in RBC count occurs as a compensation, there there is anemia in all types of alpha and Beta thalassemia . So, RBC count should increase in all other types but doesn't happen so. Next, damaged RBC is not only seen in B-thal major, also seen in other types, which should also be phagocytosed by splenic macropahge.


Any other explanations???
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Quote:
Originally Posted by Aumsai View Post
Thanks smita . But, if increase in RBC count occurs as a compensation, there there is anemia in all types of alpha and Beta thalassemia . So, RBC count should increase in all other types but doesn't happen so. Next, damaged RBC is not only seen in B-thal major, also seen in other types, which should also be phagocytosed by splenic macropahge.


Any other explanations???
there is anemia because the bone marrow tries to release the rbcs in their immature state and hence the increase in reticulocytes and persistent anemia

what i feel is that in beta thal minor and alpha thal wid oly 2 gene defect, it is only a minor condition and generally do not much of the signs....the prob starts in beta thal major and in alpha thal 3 or 4 chain defect where there is an obvious defect in rbc so that it is recognised by the speeln and phagocytosed

its just my view though
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