Pseudostratified glandular epithelium with interspersed foci of normal startified squamous epithelium - USMLE Forums
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Old 02-13-2012
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Lungs Pseudostratified glandular epithelium with interspersed foci of normal startified squamous epithelium

A 40-year old man has had progressive shortness of breath for 3 years. He has smoked 2 packs of cigarettes daily for 20 years. Examination of the bronchial mucosa obtained on biopsy shows ciliated, pseudostratified glandular epithelium with interspersed foci of normally maturing, startified squamous epithelium overlying an intact basement membrane. Which of the following processes is the most likely explanation for these findings?

A. Glandular dysplasia
B. Glandular hyperplasia
C. Glandular metaplasia
D. Squamous dysplasia
E. Squamous hyperplasia
F. Squamous metaplasia.
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D.....
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A. Glandular dysplasia
B. Glandular hyperplasia
C. Glandular metaplasia
D. Squamous dysplasia
E. Squamous hyperplasia
F. Squamous metaplasia.
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Ans ....F........
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it is f
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But it does not penetrate basement membrane
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Quote:
Originally Posted by jinni View Post
But it does not penetrate basement membrane
why does it has to penetrate BM?
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Old 02-14-2012
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It's f for me.If all step 1 questions were as straight forward as this one,i'd be glad.
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can someone explain how i should approach this question? i have no idea how to derive the answer.
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Quote:
Originally Posted by khushi.chahal View Post
can someone explain how i should approach this question? i have no idea how to derive the answer.
1- figure out the normal lining of the respi tract-- which is ciliated columnar with goblet cells

2 --- what are squamous cells doing there???

3-- oooh! it must be metaplasia... cos they are not invading.. but are at an abnormal place/.... so the columnar is changing to squamous!

much like in barrets esophagus!



(dont mind the humor.. exam tomorrow.. so goign a lil crazy!)

Last edited by mbbs2010; 02-14-2012 at 09:54 AM.
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all the best .........
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Old 02-14-2012
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Quote:
Originally Posted by mbbs2010 View Post
1- figure out the normal lining of the respi tract-- which is ciliated columnar with goblet cells

2 --- what are squamous cells doing there???

3-- oooh! it must be metaplasia... cos they are not invading.. but are at an abnormal place/.... so the columnar is changing to squamous!

much like in barrets esophagus!



(dont mind the humor.. exam tomorrow.. so goign a lil crazy!)
thanks, i think i just got lost in all the big words lol

goodluck tomorrow!
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