Inhibition of the mitogenic signal of platelet-derived growth factor - USMLE Forums
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Old 02-13-2012
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Biochemistry Inhibition of the mitogenic signal of platelet-derived growth factor

A 69-year old woman is brought to the ER with after the sudden onset of crushing, substernal chest pain and nausea. A diagnosis of myocardial infarction of the anterior wall is made. Activation of platelets and segmented neutrophils during thrombogenesis in this patient caused the release of cytokines, including platelet-derived growth factor. The mitogenic signal provided by this cytokine to smooth muscle cells at sites of vascular injury in this patient is most likely to be inhibited by which of the following intracellular enzymes?

A. Aminotransferase
B. Glycosylhydrolase
C. Kinase
D. Lipase
E. Peroxidase
F. Phosphatase
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C. Kinase
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Default mmMm

I would say Phosphatase as PDGF follow kinases and that phosphorylates, taking the phosphate out would screw the cytokine? i suck at this tho so im sure IM wrong!
and Jinni i think it means what would screw the activity , not activate it .. however i repeat I suck at this!
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yes i think it says inhibited i missed that part i would go with you now
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A. Aminotransferase
B. Glycosylhydrolase
C. Kinase
D. Lipase
E. Peroxidase
F. Phosphatase
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Ans ........F.........
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f
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I would say... F...
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