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Old 09-21-2015
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Default Methanol poisoning

Methanol poisoning is dangerous because it can metabolize to formic acid. This causes anion-gap acidosis and is toxic.

But this got me thinking: why can't metabolism of ethanol, to acetic acid, cause anion gap acidosis? and why isn't acetic acid toxic?

I mean, obviously it's not toxic, since it's ubiquitous in the body. But, why isn't it, from a biochemical perspective?
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Old 09-23-2015
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Because it is converted to acetyl CoA which enters TCA cycle
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Old 09-29-2015
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Quote:
Originally Posted by datson View Post
Because it is converted to acetyl CoA which enters TCA cycle
Thank you very much for your reply.

I wrote up this fact, and a lot of other details about methanol toxicity, in this blog post. I hope that you will read it and find it helpful.
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