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  #1  
Old 02-14-2012
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Question Cellular membrane swelling!

hey guys i did an offline nbme and got a question about...


a lady had an ischemic region in her heart which displayed mitochondrial swelling and depletion of glycogen granules, and then it asked what was the cause of these cellular changes.

the answer apparently is degradation of membrane phospholipid.
but i thought swelling was indicative of reversible cell damage, which is due to the pumps failing and therefore influx of sodium, which draws in water and causes swelling.
so to me, the answer is influx of sodium

where am i going wrong?
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Old 02-14-2012
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well as u explain the question u seem to be right but it cant be in that , can u right the complete q so that one can answer it ,,
which NBME did u do????
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Old 02-14-2012
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I know the Qs , dont remember but i think its NBME 1 , and i know the ans is given as degradation of membrane phospholipid but the correct ans is ATP depletion ...... i think that one of the options ........

do one thing write the qs no and the section no ... and then we can find it ...
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Old 02-15-2012
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Originally Posted by Hitman View Post
I know the Qs , dont remember but i think its NBME 1 , and i know the ans is given as degradation of membrane phospholipid but the correct ans is ATP depletion ...... i think that one of the options ........

do one thing write the qs no and the section no ... and then we can find it ...
yes, atp depletion is an option
and actually that would make sense because its that atp depletion that causes the sodium-potassium atp-ase to fail in the first place.

thanks!
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Old 02-15-2012
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Quote:
Originally Posted by Hitman<br />
I know the Qs , dont remember but i think its NBME 1 , and i know the ans is given as <b>degradation of membrane phospholipid</b> but the correct ans is ATP depletion ...... i think that one of the options ........<br />
<br />
do one thing write the qs no and the section no ... and then we can find it ...
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Originally Posted by khushi.chahal View Post
yes, atp depletion is an option
and actually that would make sense because its that atp depletion that causes the sodium-potassium atp-ase to fail in the first place.

thanks!
Yes, totally agree with both of us, also make sense because the ATP depletion cause the shut down of the Na/K pump but also activate the Ca/Na pump to take rid of the excess of Na, but the influx of Ca also activate the Lysosomes who contain enzymes that denature proteins and degrade the membranes and that's is precisely what cause the irreversible damage of the mytho and the nucleus.... I don't know if that's alright but that is the way how I connect it.
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Default Hospitals near Marathahalli

Enzyme activity can be affected by other molecules. Many drugs and poison are enzyme inhibitors.
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Originally Posted by cabreravelezmd View Post
Yes, totally agree with both of us, also make sense because the ATP depletion cause the shut down of the Na/K pump but also activate the Ca/Na pump to take rid of the excess of Na, but the influx of Ca also activate the Lysosomes who contain enzymes that denature proteins and degrade the membranes and that's is precisely what cause the irreversible damage of the mytho and the nucleus.... I don't know if that's alright but that is the way how I connect it.

yes your right but ...Ca influx cause irreversible damage and Atp depletion reversible ........
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Old 02-16-2012
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yes your right but ...Ca influx cause irreversible damage and Atp depletion reversible ........
Well I am now a little confuse, but as I understand the question is straight forward to irreversible MI, the Na influx, and the ATP depletion it is part of the process, the glycogen depletion approach me to a straight forward question, the Ca influx and the phospholipids damage by the activation of phosphilipases is the next and final step.
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Originally Posted by cabreravelezmd View Post
Well I am now a little confuse, but as I understand the question is straight forward to irreversible MI, the Na influx, and the ATP depletion it is part of the process, the glycogen depletion approach me to a straight forward question, the Ca influx and the phospholipids damage by the activation of phosphilipases is the next and final step.
i saw the cell swelling and assumed reversible damage, im not sure what the glycogen depletion part indicated
also, if it is a MI then i guess by definition it is irreversible damage and not reversible damage

so we're back to square one... lol
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Originally Posted by khushi.chahal View Post
i saw the cell swelling and assumed reversible damage, im not sure what the glycogen depletion part indicated
also, if it is a MI then i guess by definition it is irreversible damage and not reversible damage

so we're back to square one... lol

no its a reversible damage ...... see FA page 221 2011 edition....VIMP difference to learn ...
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