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Old 02-15-2012
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Question C1-INH deficiency causes decreased C4?

how so?

i got a question that the best way to support a diagnosis of hereditary angioedema is to find decreased concentration of C4.
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Old 02-15-2012
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I think it is the opposite as in hereditery angioedema decrease c1 esterase inhibitor which lead to c1 activation and that lead to c4 activation in turn
that is what I know
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Old 02-16-2012
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Post Thats half the story

Quote:
Originally Posted by rose View Post
I think it is the opposite as in hereditery angioedema decrease c1 esterase inhibitor which lead to c1 activation and that lead to c4 activation in turn
that is what I know
Yes, there will be C1 and C4 activation, due to which these factors will be overused.. Hence the low levels of C4!
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