Missing Beta 2 Microglobulin - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 04-07-2010
Yallah's Avatar
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 81
Threads: 59
Thanked 174 Times in 43 Posts
Reputation: 184
Question Missing Beta 2 Microglobulin

Transgenic mice are generated which are incapable of expressing beta 2 microglobulin. Which of the following components of host defense is most likely to be altered in these mice?

A- Complement
B- Cytotoxic T lymphocytes
C- Interleukin 2 (IL2) secretion
D- Natural killer cells
E- Neutrophils
Reply With Quote Quick reply to this message
The above post was thanked by:
drortho (01-18-2012), Taiwan_Guy (05-19-2011)



  #2  
Old 04-07-2010
Seetal's Avatar
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 919
Threads: 134
Thanked 1,310 Times in 364 Posts
Reputation: 1333
Send a message via MSN to Seetal
Default

cytotoxic t lymhocytes.
Reply With Quote Quick reply to this message
  #3  
Old 04-07-2010
Sarah-cali's Avatar
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 63
Threads: 12
Thanked 148 Times in 44 Posts
Reputation: 168
Default

Quote:
Originally Posted by Seetal View Post
cytotoxic t lymhocytes.
I agree with you
Reply With Quote Quick reply to this message
 
  #4  
Old 11-18-2011
dr.muhamad's Avatar
USMLE Forums Guru
 
Steps History: 1 + CS
Posts: 300
Threads: 22
Thanked 97 Times in 62 Posts
Reputation: 107
Default

isnt it LAD type 2??
and the answer is E??
Reply With Quote Quick reply to this message
  #5  
Old 11-18-2011
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 154
Threads: 8
Thanked 134 Times in 62 Posts
Reputation: 144
Default

Quote:
Originally Posted by dr.muhamad View Post
isnt it LAD type 2??
and the answer is E??
Hey dr. muhamad I think beta2 microglobulin is part of the MHC 1 complex, which interacts with Cytotoxic t lymphocytes. So without this they probably cant be activated.
Reply With Quote Quick reply to this message
The above post was thanked by:
dr.muhamad (11-18-2011)
  #6  
Old 11-18-2011
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 154
Threads: 8
Thanked 134 Times in 62 Posts
Reputation: 144
Default

P.S in LAD 2 it is an integrin defect, not microglobulin.
Reply With Quote Quick reply to this message
The above post was thanked by:
dr.muhamad (11-18-2011)
  #7  
Old 11-18-2011
dr.muhamad's Avatar
USMLE Forums Guru
 
Steps History: 1 + CS
Posts: 300
Threads: 22
Thanked 97 Times in 62 Posts
Reputation: 107
Default

Quote:
Originally Posted by Glomerulus View Post
P.S in LAD 2 it is an integrin defect, not microglobulin.
oh thanks
i thought they r both microglobulin
Reply With Quote Quick reply to this message
  #8  
Old 11-18-2011
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 154
Threads: 8
Thanked 134 Times in 62 Posts
Reputation: 144
Default

Quote:
Originally Posted by dr.muhamad View Post
oh thanks
i thought they r both microglobulin
I dont think so. I have read that LAD 1 is an integrin defect and LAD 2 a selectin defect, but extremely rare.
Reply With Quote Quick reply to this message
  #9  
Old 11-18-2011
USMLE Forums Scout
 
Steps History: 1 + CK
Posts: 22
Threads: 4
Thanked 2 Times in 2 Posts
Reputation: 12
Default

cytotoxic t lympocytes
Reply With Quote Quick reply to this message
  #10  
Old 11-18-2011
USMLE-Syndrome's Avatar
USMLE Forums Master
 
Steps History: ---
Posts: 1,203
Threads: 180
Thanked 1,251 Times in 441 Posts
Reputation: 1265
Default

B- Cytotoxic T lymphocytes
Reply With Quote Quick reply to this message
  #11  
Old 12-18-2011
MedPharm's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 106
Threads: 9
Thanked 73 Times in 43 Posts
Reputation: 83
Default

B...
beta2microglobulin is the part of the MHC1 that is not encoded in the HLA-gene-complex. the MHC1 is used as an 'ID' for cells, so they are left unharmed by the cytotoxic CD8.

hope I'm right
Reply With Quote Quick reply to this message
  #12  
Old 12-18-2011
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 11
Threads: 2
Thanked 1 Time in 1 Post
Reputation: 11
Default

answer is B.cytotoxic T-cells.!
becoz MCH-1 is cytotoxic expressd on all the nucleatd cells in the body , beta2 micro transports antigen to cell surface through exogenous pathway and its not encoded in MCH1. so its mutation affects cytotoxic T cells.
Reply With Quote Quick reply to this message
  #13  
Old 12-18-2011
Dr. Mexito's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 662
Threads: 72
Thanked 369 Times in 204 Posts
Reputation: 379
Correct Answer Same here...

I think is B. I do not add anything more to the explanation, as the most important concepts have already been said.
Reply With Quote Quick reply to this message
  #14  
Old 12-18-2011
USMLE Forums Veteran
 
Steps History: Not yet
Posts: 281
Threads: 74
Thanked 131 Times in 68 Posts
Reputation: 141
Thumbs Up

correct ans in B.
Reply With Quote Quick reply to this message



Reply

Tags
Immunology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
21 versus 11 beta hydroxylase deficiencies StepTaker USMLE Step 1 Bits & Pieces 3 02-06-2017 09:45 AM
Beta Hemolytic Microorganisms lee-usmle USMLE Step 1 Buzzwords 1 09-18-2011 11:18 AM
Missing the major diagnosis? examinitis USMLE Step 2 CS Recommended Threads 1 01-08-2010 11:24 PM
Beta One Selective Beta Blockers rasheed USMLE Step 1 Mnemonics 3 11-26-2009 09:12 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)