Mechanism of action of Propylthiouracil - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Drug Mechanism of action of Propylthiouracil

A 47 year woman come to the physician because of nervousness and sensitivity to warm temperature. Diagnosis of hyperthyroidism is made and treat with PTU. Wich of the following best describe the mechanism of action of this drug?

A- Decrease the efficacity of TSH binding to the TSH receptor
B- DEcrease the rate of proteolysis of thyroglobulin
C- increase the amount of 3',5'-triiodothyronine(reverse T3[rT3])
D- Inhibit the uptake of Iodide into the thyroid gland
E- interfere with the 1st step in thyroid hormone biosynthesis
Reply With Quote Quick reply to this message



  #2  
Old 02-18-2012
USMLE Forums Veteran
 
Steps History: Not yet
Posts: 270
Threads: 34
Thanked 221 Times in 119 Posts
Reputation: 231
Default

E..........
Reply With Quote Quick reply to this message
  #3  
Old 02-18-2012
shafaliMD's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 8 Times in 7 Posts
Reputation: 18
Default

E!

inhibits the oxidation of iodide to iodine therefore inhibiting thyroid peroxidase! :-) yay
Reply With Quote Quick reply to this message
  #4  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

Quote:
Originally Posted by shafaliMD View Post
E!

inhibits the oxidation of iodide to iodine therefore inhibiting thyroid peroxidase! :-) yay

But in the answers of choice your explanation not found
Reply With Quote Quick reply to this message
  #5  
Old 02-18-2012
shafaliMD's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 8 Times in 7 Posts
Reputation: 18
Idea!

i am actually in pharmacology currently and we just learned endocrine and its drugs.
Reply With Quote Quick reply to this message
  #6  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

Ok. What book you use for pharmac and endocrinology
Reply With Quote Quick reply to this message
  #7  
Old 02-18-2012
shafaliMD's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 8 Times in 7 Posts
Reputation: 18
Thumbs Up

welll.... theoretically my professor has compiled his own book. which is great b/c most of the things are already in a book. but mostly everything in his book can be found in kaplan videos
__________________
GuberNacUlum's the name and GuBERnacuLUMS the game
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
The above post was thanked by:
alfjof (02-18-2012)
  #8  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

I got the Kaplan pharmacology cd but no all chapter that is the reason so I apreciate your information
Reply With Quote Quick reply to this message
  #9  
Old 02-18-2012
shafaliMD's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 8 Times in 7 Posts
Reputation: 18
Default

no problems... feel free to message me again.... if u want to work on some questions together?
__________________
GuberNacUlum's the name and GuBERnacuLUMS the game
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #10  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

I got more than 50 questions so I will have to post them in the forum what do you thinK?
Reply With Quote Quick reply to this message
  #11  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

In 10 minutes I will post a new question let me know if you ready
Reply With Quote Quick reply to this message
  #12  
Old 02-18-2012
shafaliMD's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 8 Times in 7 Posts
Reputation: 18
Default

me's ready
__________________
GuberNacUlum's the name and GuBERnacuLUMS the game
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #13  
Old 02-18-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 104 Times in 62 Posts
Reputation: 114
Send a message via Yahoo to alfjof
Default

I posted it in the forum do you see it
Reply With Quote Quick reply to this message
  #14  
Old 08-06-2012
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 85
Threads: 13
Thanked 22 Times in 15 Posts
Reputation: 32
Search Propylthiouracil

Propylthiouracil blocks the organification of iodine and coupling of mono and di iodo tyrosine it also prevents the peripheral convrsion of T4 to T3.Perchlorate and pertecnaetate inhibit peroxidase.Thus the answer should be C not E I think
__________________
preeti
Reply With Quote Quick reply to this message
  #15  
Old 12-09-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 11
Threads: 0
Thanked 10 Times in 6 Posts
Reputation: 20
Default

hey preeti.. you said, "Propylthiouracil blocks the organification of iodine and coupling of mono and di iodo tyrosine it also prevents the peripheral convrsion of T4 to T3." that is correct, and remember Methimazole doesn’t do the latter. However, Perchlorate and pertecnaetate inhibit uptake of iodide into the thyroid gland.. i.e. basically if either of these increase, then they are going to decrease iodide to be taken into the organ because they all use the same transport system.
hope that makes sense!
Reply With Quote Quick reply to this message
The above post was thanked by:
savleem (12-09-2012)






Reply

Tags
Pharmacology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Mechanism of action of Ipratropium scopusmount USMLE Step 1 Forum 4 11-11-2011 12:40 PM
Mechanism of action! hope007 USMLE Step 1 Forum 0 10-09-2011 12:23 AM
Mechanism of action of these drugs... bebix USMLE Step 1 Forum 5 06-20-2011 05:57 AM
Fibrates Mechanism of action? LionofJudo USMLE Step 1 Forum 5 07-23-2010 07:22 PM
Thiozolidinediones Mechanism of Action Ahmed-USMLE USMLE Step 1 Bits & Pieces 0 11-29-2009 06:18 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)