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Old 10-03-2015
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Default Diastolic dysfunction

Why is left ventricular end diastolic volume normal in diastolic dysfunction?
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Old 10-03-2015
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Quote:
Originally Posted by Doctor M View Post
Why is left ventricular end diastolic volume normal in diastolic dysfunction?
S3 = increased volume
- Increased volume will stretch the muscle fibers of the ventricles which will not allow them to contract properly
- This will give you SYSTOLIC dysfunction as the heart wont be able to contract

S4 = increased pressure (resistance)
- Increased resistance or pressure to pump against (stiff ventricle) will NOT allow the ventricles to fill properly, thus giving you diastolic dysfunction
- So the EDV may be normal, but if the heart wont be able to fill properly it wont matter and you will end up with diastolic dysfunction

Hope this helped good luck
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Old 10-03-2015
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I thought I was clear on the concept but it turns out am not.
Could you give an example of a condition where EDV is normal?
And is that due to increased pressure?
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Old 10-03-2015
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Stethoscope

Quote:
Originally Posted by FarxFirstAid View Post
S3 = increased volume
- Increased volume will stretch the muscle fibers of the ventricles which will not allow them to contract properly
- This will give you SYSTOLIC dysfunction as the heart wont be able to contract

S4 = increased pressure (resistance)
- Increased resistance or pressure to pump against (stiff ventricle) will NOT allow the ventricles to fill properly, thus giving you diastolic dysfunction
- So the EDV may be normal, but if the heart wont be able to fill properly it wont matter and you will end up with diastolic dysfunction

Hope this helped good luck
I still dont get it as to how EDV will be normal? Diastolic dysfunction is mostly due to ventricular hypertrophy, therefore decreased compliance with "normal EDV". These things dont seem to fit together.
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Old 10-04-2015
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Diastolic dysfunction is present in both hypertrophic and restrictive cardiomyopathy.
In restrictive cardiomyopathy there is decreased compliance. Hence the same volume can be achieved by an increase in pressure. This is just my theory but it makes sense at least very early in the pathology.
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Old 10-04-2015
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Quote:
Originally Posted by datson View Post
Diastolic dysfunction is present in both hypertrophic and restrictive cardiomyopathy.
In restrictive cardiomyopathy there is decreased compliance. Hence the same volume can be achieved by an increase in pressure. This is just my theory but it makes sense at least very early in the pathology.
Diastolic Dysfunction is caused by both Restrictive and hypertrophic.

And yeah increase in pressure will cause normal filling makes sense.

Thanks!
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