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Old 10-12-2015
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Question Physiology behind "hot flashes" in menopause

guys what is the physiology behind hot flashes?

is the problem behind the hypothalamus not secreting enough GnRH the problem behind "hot flashes" or is it more involved with the ovaries themselves?

Thanks in advance!
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Old 10-13-2015
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Quote:
Originally Posted by Virgo11 View Post
guys what is the physiology behind hot flashes?

is the problem behind the hypothalamus not secreting enough GnRH the problem behind "hot flashes" or is it more involved with the ovaries themselves?

Thanks in advance!
There is a surge of estrogen that happens during menopause

Basically your brain senses that there is not enough estrogen being produced and a small surge of estrogen is created

If you remember estrogen is a potent vasodilator, so that surge will cause vasodilation of the blood vessels and that hot flash sensation

It can be quite confusing to think of a tiny surge of estrogen in menopause since menopause is literally decreased estrogen and increased FSH/LH but two different professors explained it this way

The surge is not enough to raise the overall levels of estrogen but just enough to produce the vasodilation that makes the pt hot
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Old 02-03-2016
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Default Dwindling Estrogen Levels

It's as simple as that.

As we age, changes in our estrogen levels is the main reason why we get hot flushes and all other symptoms of menopause and right now one of the most effective way to treat this is with hormone therapy.
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Old 02-03-2016
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One long-standing assumption has been that hot flashes
involve transient dysregulation of the thermoregulatory system,
triggering homeostatic heat loss mechanisms to return the system
to normal. During a hot flash, many of the easily observed
physiological changes involve the thermoregulatory and vascular
systems. This remains an area of incomplete research.




Clearly, estrogen plays some role as a mediator of hot flashes.
Hot flashes occur as estrogen levels decline and they are alleviated
for the most part by treatment with estrogen (9). Estrogen
priming is likely important. Young women with low estrogen
levels do not have hot flashes, but if given estrogen and then
withdrawn from it, they will have hot flashes.
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