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Old 02-25-2012
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Question DKA and cell membrane signaling

A 10-year-old boy is brought to the emergency department because of vomiting for 6 hours. He has had excessive
thirst and excretion of large amounts of urine for 3 weeks. His pulse is 120/min, and respirations are 32/min.
Physical examination shows sunken eyes and diminished skin turgor. Serum studies show hyperglycemia, ketosis,
and metabolic acidosis. Urine studies show glucose and ketones. Which of the following sets of hepatic findings is
most likely in this patient?

Protein Kinase A/Phosphoprotein Phosphatase/cAMP
(A) ↑ ↑ ↓
(B) ↑ ↓ ↑
(C) ↑ ↓ ↓
(D) ↓ ↑ ↑
(E) ↓ ↓ ↑
(F) ↓ ↓ ↓

the answer is B but i didnt get it
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Old 02-25-2012
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insulin stimulates the phosphatases and inhibits the kinases

therefore diabetes (lack of insulin) will cause increased kinases and decreased phosphatases.

how cAMP comes into play im not sure...
"inflammable means flammable!? What a country."
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The above post was thanked by:
gear2d (02-25-2012)
Old 02-25-2012
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protein kinase stimulates adenyl cyclase which increases production of cAMP
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The above post was thanked by:
docwedsengr27 (02-25-2012), Dr.NickRiviera (02-25-2012)


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