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Old 02-26-2012
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Help Breast histology

Can anyone please give a site where normal histology of breast ducts are explained..i mean those carcinomas and paget's disease related histologies ..i want to know the normal histological features..really feeling confused about the histology of those disease without knowing normal histology...please a link...
@suka@xapeaz@d-wiqed..please and all other people please:sorry:
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Old 02-26-2012
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Two cell types line the ducts and lobules; epithelial cells (make milk) and underlying myoepithelial cells (contractile function).

Benign cancers are profilerations of both.
Malignannt cancers are proliferations of just the epithelial cells.

Other than that you should know theres fat in the breast and damage to the fat will lead to fat necrosis and calcification.

The other two times you will see calcification in the breat are sclerosing adenosis (a fibrocystic change) and comedocarcinoma (an intraductal carcinoma in situ)

This is off the top of my head so do correct me if im wrong.
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Old 02-26-2012
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I just googled it... Try this link:

http://www.pathpedia.com/education/e...st/Images.aspx

There are cross-sections of a normal duct, lobule, etc where the cancers originate.

Also, Atlas of Pathology by Robbins and Cotran shows you a whole chapter on slides of normal breasts then slides of the different malignancies. I felt that it was very useful to me in understanding the histology of the diseases.

If you need to go in-depth on the epithelial lining, I included below a page from Wheater's Histology Atlas.

Basically, it's just like Dr.Nick said. There are many different types of breast cancers but to understand them, all you need to know is 1. what is a duct and 2. what is a lobule.

If you're still confused after the link above, maybe what you only need is an overview or a bird's-eye view of the structure of the breast. Not really the histology of the normal breast but how structures are oriented to each other.

Good luck!
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Breast histology-normalbreastslides.jpg   Breast histology-normalbreastcaption.jpg  
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Quote:
Originally Posted by Dr.NickRiviera View Post
Two cell types line the ducts and lobules; epithelial cells (make milk) and underlying myoepithelial cells (contractile function).

Benign cancers are profilerations of both.
Malignannt cancers are proliferations of just the epithelial cells.

Other than that you should know theres fat in the breast and damage to the fat will lead to fat necrosis and calcification.

The other two times you will see calcification in the breat are sclerosing adenosis (a fibrocystic change) and comedocarcinoma (an intraductal carcinoma in situ)

This is off the top of my head so do correct me if im wrong.
thank u so much..got a hang of it now somewhat...and yeah those things make me too
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Old 02-27-2012
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Quote:
Originally Posted by d_wiqed View Post
I just googled it... Try this link:

http://www.pathpedia.com/education/e...st/Images.aspx

There are cross-sections of a normal duct, lobule, etc where the cancers originate.

Also, Atlas of Pathology by Robbins and Cotran shows you a whole chapter on slides of normal breasts then slides of the different malignancies. I felt that it was very useful to me in understanding the histology of the diseases.

If you need to go in-depth on the epithelial lining, I included below a page from Wheater's Histology Atlas.

Basically, it's just like Dr.Nick said. There are many different types of breast cancers but to understand them, all you need to know is 1. what is a duct and 2. what is a lobule.

If you're still confused after the link above, maybe what you only need is an overview or a bird's-eye view of the structure of the breast. Not really the histology of the normal breast but how structures are oriented to each other.

Good luck!
thank u so much for the wonderful quotation and pic of robbins..thanks mate..and yeah looking up the site now..so kind of u ..thanks thanks
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