why large muscle mass causes lowee eGFR? - USMLE Forums
 USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
 Home USMLE Articles USMLE News USMLE Polls USMLE Books USMLE Apps
 USMLE Forums why large muscle mass causes lowee eGFR?
 Register FAQs Members List Search Today's Posts Mark Forums Read

 USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

#1
10-24-2015
 USMLE Forums Veteran Steps History: Not yet Posts: 213 Threads: 54 Thanked 53 Times in 41 Posts Reputation: 63
why large muscle mass causes lowee eGFR?

Why.? Thanks

#2
10-25-2015
 USMLE Forums Scout Steps History: Step 1 Only Posts: 23 Threads: 6 Thanked 11 Times in 6 Posts Reputation: 21

GFR = ClearanceCR = Urine Cr x Urine Flow / Plasma Creat

Increased muscle mass ---> Increased Plasma Cr! Now if you do the old 24 hr method of collecting urine , you will see that Urine Cr increases too so it will be accurate .. But if you use the equations that you just put the Plasma Cr , they will obviously underestimate the GFR ( e.g bodybuilder may have 2.0 mg/ml serum Cr , which puts him in renal failure range , but actually he has no kideny problem at all)

Appreciate that this is the Calculated GFR only , in reality muscle mass by itself will not change the actual GFR

Last edited by tassosant13; 10-25-2015 at 04:16 AM. Reason: typo

Message:
Options

## Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
User Name:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
 AMG IMG ---
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

 Not yet Step 1 Only CK Only CS Only 1 + CK 1 + CS 1+CK+CS CK+CS 1+CK+CS+3 ---
Favorite USMLE Books
 What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
 Where you live. Leave blank if you don't want to tell.

## Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.