question about warfarin - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-03-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 62
Threads: 29
Thanked 11 Times in 9 Posts
Reputation: 21
Default question about warfarin

Warfarin -i was told -- u follow PT -

- i got this kaplan question that essential says - if u give -- warfarin+p450 inb. ,
warfarin also increases PTT -- question id- m200804m.seq

- now this makes sense since-- wafarin effects - 10,9,7,2,c,s -- which overlaps with PTT's coverage --factors 10,9,2,c,s -- overlap.

my question is -- why only an increased dose of warfarin effects PTT, while a normal dose doesnt.

ty
Reply With Quote Quick reply to this message



  #2  
Old 03-03-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 62
Threads: 29
Thanked 11 Times in 9 Posts
Reputation: 21
Default

never found answer ; ) .

- normal does only - affects 7

- need really high warfarin dose - or vit K def - to affect rest
Reply With Quote Quick reply to this message
  #3  
Old 03-03-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 873 Times in 506 Posts
Reputation: 886
Default

maybe because under normal conditions most of the Warfarin is bound to protein, but if you inhibit its metabolism by p450 you will cause more free drug in blood ?
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
  #4  
Old 03-03-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 62
Threads: 24
Thanked 7 Times in 7 Posts
Reputation: 17
Default

It is a very moot point.. and thats why I don't like Kaplan Qbank sometimes.

Goljan pg 256 3rd ed.

Hep and Warfarin both increase PT and PTT.
But in clinical practice PT is better for Warf. and PTT for HEP.
Reply With Quote Quick reply to this message
The above post was thanked by:
DocSikorski (03-03-2012)



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Warfarin + TMP/SMX Seetal USMLE Step 1 Forum 7 01-30-2016 01:50 PM
Vitamin E and Warfarin Interaction! zohaib USMLE Step 1 Forum 3 12-06-2011 08:56 PM
Doubt about heparin and warfarin dr_mhm USMLE Step 2 CK Forum 5 10-07-2011 09:24 PM
Which drug potentiated Warfarin? step1an USMLE Step 2 CK Forum 10 09-14-2011 09:56 AM
How Warfarin can cause hypercoagulation if given without Heparin? donofitaly USMLE Step 1 Forum 4 12-04-2010 03:12 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)