Urobilinogen in various types of Jaundice! - USMLE Forums
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Old 03-03-2012
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Liver Urobilinogen in various types of Jaundice!

I just cant understand increase urobilinogen (urine urobilin) in hemolytic anemia (in heamolytic we only have unconjugated bilirubin so why increase urobilinogen)??
In hepatocellular jaundice, does the conjugated bilirubin and urobilinogen increase? and why ?

This is confusing to me
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Old 03-03-2012
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In extra-vascular hemolysis the UGT becomes saturated hence an increase in unconjugated Bilirbuin (UCB). However the enzyme is still functioning and therefore you are still getting conjugated Bilirubin, which is converted to urobilinogen.

So think of it like the enzyme normally makes 50 CB at a time and reaches saturation at 75. So at saturation not only would UCB increase but CB will also be slightly increased but not to a pathological level.
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Gastrointestinal-Tract-, Pathology-, Physiology-

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