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Old 03-05-2012
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Default acetaminophen causes centrilobular necrosis

acetaminophen causes centrilobular necrosis. any 1 can explain what it means and what is the reason?
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Old 03-05-2012
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Acetaminophen - think of it as a free radical, and the most common target of free radicals are liver and kidneys

In your question, it tends to attack the liver surrounding the central vein, hence centrilobular necrosis.

Source: Goljan
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Old 03-05-2012
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Its simple if you understand the fact that the zones in liver are present between portal triad and central vien into 3 the one closer to portal triad is zone 1 and the one near central vien is zone 3.Since the zone 3 is the one recieving leas amount of O2 because its farthes from the portal triad(containg hepatic artery).
Any hypoxia or as in this case acetaminophen decrease the glutathione stores increase the amount of O2 free radical in the area of zone 3 because of least O2 supply so thats why its around central vien.
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