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Old 03-05-2012
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Default Nbme 11 question #1

A 65-y-old man undergoes an operation to remve an abdomminal mass. Histologic examination of the mass shows a large number of blood vessels. Further analysis shows an increased concentration of VEGF in the tumor. Which of the following most likely stimulated the production of VEGF in the mass of the patient.

A) Increased endostatin
B) Decreased endostatin
C) Decreased Pco2
D) Decreased Po2
E) Decreased thromboplastin
E) Increased Po2
F) Increased Pco2
G) Increased thrombospondin

Please answer and explain
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Old 03-05-2012
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well it has to be decreased thrombospondin response..becuase thrombospondin is an antiangigenec factor..but the answer key that i downloaded surprisingly said increased thrombospondin..they i am sure are wrong
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Old 03-05-2012
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the growing tumor will need more oxygen ,which causes VEGF to increase ,causing proliferation of blood vessels.

same reason for wet ARMD (acute retinal macular degeneration)in which low oxygen causes increase in VEGF resulting in neovascularization and central scotoma. Rx -anti-VEGF therapy (very imp)

So answer in D -low oxygen

learn the association .low oxygen triggers -VEGF -neovascularization -Rx anti VEGF
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Quote:
Originally Posted by avash.nrs View Post
well it has to be decreased thrombospondin response..becuase thrombospondin is an antiangigenec factor..but the answer key that i downloaded surprisingly said increased thrombospondin..they i am sure are wrong
This question kinda discouraged me, i spent like 2 minutes trying apply the logic, but then I remembered, that in kids born preterm due to surfactant deficit they were treated with oxygen or something and it caused the vasculogenesis in the eyes.... So I answered - Increased p02 which was wrong.

Silly mistake. I was also thinking that it has got to be decreased pO2, but this random thought about baby with o2 made me choose the wrong one.

It has to be decreased pO2.
ppl on other forums also say that... But what do you guys think?
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Quote:
Originally Posted by DocSikorski View Post
This question kinda discouraged me, i spent like 2 minutes trying apply the logic, but then I remembered, that in kids born preterm due to surfactant deficit they were treated with oxygen or something and it caused the vasculogenesis in the eyes.... So I answered - Increased p02 which was wrong.

Silly mistake. I was also thinking that it has got to be decreased pO2, but this random thought about baby with o2 made me choose the wrong one.

It has to be decreased pO2.
ppl on other forums also say that... But what do you guys think?
but u see well..its an old man with an abdominal tumour and tumour needs angiogenesis..so dont u think thrombospondin is important here??i personally think thrombospondin is the answer here decreased level of it...increased angiogenesis due to increase VEGF...
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Quote:
Originally Posted by step_enhancer View Post
the growing tumor will need more oxygen ,which causes VEGF to increase ,causing proliferation of blood vessels.

same reason for wet ARMD (acute retinal macular degeneration)in which low oxygen causes increase in VEGF resulting in neovascularization and central scotoma. Rx -anti-VEGF therapy (very imp)

So answer in D -low oxygen

learn the association .low oxygen triggers -VEGF -neovascularization -Rx anti VEGF
Was writing a post at the same time as you in here!
Thank you! Thats where I got it wrong.
I need to find that concept with a baby and oxygen therapy and make it clear for myself...
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as i searched google..it can be useful to solve the mystery with this qs...
www.ncbi.nlm.nih.gov/pubmed/20923780
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Old 03-11-2014
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YES!! it is decreased P02, i answered that and it didnt show in my mistakes.
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Old 03-11-2014
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I don't think I heard it in Goljan, but definitely in Pharm class. I feel like I've seen it pop up a lot in the q banks. Def one to know.

(I just deleted the post because I hadn't realized it had already been answered - forum newb lol)
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hahahaa i deleted mine due to your deletion, it seemed weird posting something that didnt make sense.
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