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Old 03-05-2012
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Question Hepcidin

well plz some one help me sort ou this plz...in uworld there is written in acute phase inflammation there is increased hepcidin activity..low ferroportin activity and low iron absorbtion from gut..and decreades iron release from the macrophages..but i knew fenton reaction needed iron right??and this reaction needs macrophages right??so does sound anamolous...please somebody ex:sorrylain this plzz
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Old 03-05-2012
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fenton rxn is just something that produces free radicals from iron and is only really important when you have excess iron (therefore excess free radicals and damage to tissues).

so in a case like this where you have decreased iron in the body, im not sure what the importance of fenton pathway is.
in my mind, fenton pathway is only important when you have to much iron.
so i dont see the connection you are trying to establish.
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Old 03-05-2012
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Hepcidin is released too protect the body , esp against micro organism ( too make sure they dont use any of the bodys iron)
Anemia of Chronic dis - the system is confused causing iron to be locked up in the wrong situation which leads to microcytic anemia
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Old 03-05-2012
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Quote:
Originally Posted by Dr.NickRiviera View Post
fenton rxn is just something that produces free radicals from iron and is only really important when you have excess iron (therefore excess free radicals and damage to tissues).

so in a case like this where you have decreased iron in the body, im not sure what the importance of fenton pathway is.
in my mind, fenton pathway is only important when you have to much iron.
so i dont see the connection you are trying to establish.
yup..too much iron causes fenton reaction and well correct me if i am mistaken it is used by body defense to kill microorganism during acute phase...well that why i was asking...hepcidin blocking iron absorbtion means defiency of iron..so acute phase reaction will be hampered..well i may be mistaking..thats why asked for u all to bail me out..thanks a lot
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Old 03-05-2012
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Quote:
Originally Posted by angelwork View Post
Hepcidin is released too protect the body , esp against micro organism ( too make sure they dont use any of the bodys iron)
Anemia of Chronic dis - the system is confused causing iron to be locked up in the wrong situation which leads to microcytic anemia
thanks a lot..but can u please elaborate about the chronic anaemia a bit..thanks in advance
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Old 03-06-2012
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To avash.nrs..

The above two posters explained it really well. Fenton Rxn is when you have too much Iron which causes FRs, it doesnt really have anything to do with FR killing of microbes.

Acute Inflammation simulates Infection. Therefore the body responds as if it has an infection.
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