USMLERx Question Mistake - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 03-07-2012
bunny's Avatar
Steps History: Not yet
Posts: 176
Threads: 34
Thanked 117 Times in 69 Posts
Reputation: 127
Warning! USMLERx Question Mistake

A 32-year-old man with Hodgkin’s lymphoma is scheduled to undergo a bone marrow transplant. HLA typing of his immediate family shows that his identical twin brother is a suitable match for a bone marrow graft. Which of the following grafts is most likely to be successful in this patient?

A. Allogeneic
B. Autogeneic
C. Combination graft
D. Syngeneic
E. Xenogeneic


The answer is A. An allograft is a graft taken from a genetically different member of the same species. Recipients require posttransplant immunosuppression to prevent allograft rejection. Rejection is a T-cell mediated process.

B is incorrect. An autogeneic graft, also known as an autologous or self-graft, would be a transplantation of the patient’s own tissue from one site to another. They are commonly used for skin grafts, coronary artery bypass surgery (vein), and bone or cartilage transplants. There is no need for immunosuppresion. However, an autologous graft is not an option for this patient, because Hodgkin’s lymphoma affects bone marrow throughout the body.

C is incorrect. A combination graft is usually composed of a mixture of autogeneic and allogenic tissues.

D is incorrect. A syngeneic graft is a graft harvested from a patient’s genetically identical twin sibling, and is a type of allogeneic graft. Syngeneic grafts are nearly always successful, and the recipient does not require posttransplant immunosuppression nor does he or she develop graft-versus-host disease. An allogeneic graft, harvested from another member of the same species, would be an appropriate response if this patient did not have a twin brother. It would be less successful in this case, because allograft recipients require posttransplant immunosuppression.

E is incorrect. A xenogeneic graft, or heterograft, is a graft taken from a different species. This type of graft is always rejected in an immunocompetent host.

The correct answer is D but over the website its mentioned A so be careful
Reply With Quote Quick reply to this message
The above post was thanked by:
patho2012 (03-07-2012)

Old 03-07-2012
patho2012's Avatar
USMLE Forums Veteran
Steps History: ---
Posts: 213
Threads: 13
Thanked 119 Times in 81 Posts
Reputation: 129
Default Concordance for Hodgkin disease

Hodgkin dz are mostly of 2 types: early adulthood form (15-40yo) and late adulthood form (>55yo). The risk of developing juvenile type of Hodgkin dz for identical twins (ie, monozygotic sibbling) is very high. The risk for dizygotic bro/sis is similar to that of other sibblings. Putting together, it is worth questioning to receive a syngeneic graft from an identical twin or an allograft from a normal person. I would choose a syngeneic allograft over an allogeneic graft since I have no solid experience in this field. Just my personal thought.
Reply With Quote Quick reply to this message
Old 03-07-2012
USMLE Forums Scout
Steps History: Step 1 Only
Posts: 23
Threads: 2
Thanked 7 Times in 3 Posts
Reputation: 17

I took this question in one of the Kaplan's Qbanks and the answer is D syngeneic
Reply With Quote Quick reply to this message



Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Mistake in my two digit score! NPS84 USMLE Step 1 Forum 2 01-18-2012 08:30 AM
mistake in FA 2011? USMLE2011m USMLE Step 1 Forum 1 09-11-2011 02:38 AM
LOR Name mistake annashah IMG Residency Match Forum 2 07-29-2011 04:20 PM
LoR Mistake..what to do? ayash IMG Residency Match Forum 3 07-25-2011 05:27 PM
Fatal mistake!! wayner IMG Residency Match Forum 5 08-20-2010 12:21 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)