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Old 03-08-2012
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RBC Target cells

ok so lets skip the basic defintion...i'll put that down here.

Excess RBC membrane; sign of hemoglobinopathy or alcohol excess. I know they appear in sickle disease.



Now someone tell me this important stuff.

Why do they appear???
What other diseases do they appear in???
What do they signify???
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Old 03-08-2012
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target cells are seen in thalesemia.
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Old 03-08-2012
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Also in asplenia,
Sickle cells (and also HbC)

I do not see this in the first aid, but also target cells can be present in lead poisoning as far as I remember....
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Old 03-08-2012
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They appear because you have decreased cell contents, so your membrane:cytoplasm ratio is increased.

Target cells appear in B-Thalassemia major, HbC disease, and some in Sickle cell disease.

They signify abnormal Hb?
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Old 03-08-2012
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Liver disease

Iron lack or deficiency

Post-splenectomy

Decreased lecithin cholesterol acyltransferase activity

Thalassemia (hemoglobinopathy)
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Old 10-24-2012
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According to my understanding target cells appear because of abnormal/low hemoglobin and this causes the rbc to be "less filled" in the inside and this causes the superior an inferior surfaces of the rbc to touch at the center causing the redness in the center and because of the low/abnormal hemogoblin you see white around it
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