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Old 03-08-2012
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Question Anovulation with dieting or with obesity!

I came across this question, where anorexic gal had anovulation.

I think its due to decreased fat => decreased GnRH synthesis => dicreased LH and FSH.
Hyperprolactemia makes sence also.

Now FA says that Obesity can cause anovulation - can someone explain - how?

Also i do not understand, how thyroid disorders, Cushing and adrenal insuficiency would cause anovulation...

Thank you!
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Old 03-08-2012
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you're right about anorexia
it causes decreased GnRH

not sure about thyroid hormones though...
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Well I think in Obesity there is a constant high level of estrogen(due to increased peripheral aromatisation) and this doesnt give any LH surge which is required for ovulation..

i dont know the reason behind others
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Originally Posted by vna.rao22 View Post
Well I think in Obesity there is a constant high level of estrogen(due to increased peripheral aromatisation) and this doesnt give any LH surge which is required for ovulation..

i dont know the reason behind others
This seems correct, can you be more specific - why wouldnt it surge LH?

I suck at repro...
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for ovulation to occur normally, thr has to be an estrogen surge(around 24-36 hrs before ovulation) which will then give a positive feedback to LH---LH surge--->ovulation.

Constant high levels wdnt give this surge(may be cos they are already so high)
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Anorexia:
Decreased GnRH which will cause decreased LH and FSH release causing decreased estrogen production which will cause anovulation....no Estrogen rise or LH surge.

Obesity:
More aromatase present, so endogenous androgens are greatly converted into estrogen. Since estrogen always stays high there is no normal rapidly rising estrogen that occurs in follicular phase which causes LH surge. Also increased estrogen cause negative feedback on both LH and FSH, so by these combined mechanisms, more importantly the latter....no ovulation.
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