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Old 03-09-2012
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Immunology Measuring Complement Level in Recurrent Neisseria!

i know its C5-C9 deficiency.
what do you measure?
the choices were either
a. flow cytometry
b. IgA level
c. C4 level

the correct answer is C
is it type error?
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Old 03-09-2012
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Default I think C is right

That actually seems like the best of the choices - whether C4 has been used up will be an indicator of classical vs. alternative complement pathway activation. I think C4 and C3 levels are usually ordered together. The other test that would have been appropriate is a CH50 assay, but that doesn't fit any of the foils. We do think of C5-9 deficiency with recurrent neisseria infections and C3 deficiency with recurrent pyogenic infections, but we'd want to confirm by complement panels.
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