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Old 03-09-2012
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Drug metformin doesnt cause hypoglycemia

metformin inhibits gluconeogenesis.

gluconeogenesis inhibition -> decrease in serum glucose -> hypoglycemia

but just learned that metformin does not cause hypoglycemia...

please help
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Old 03-09-2012
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yea its deffo euglycemic
it doesnt increase insulin or insulin receptors (mechanisms which could yield hypoglycemia), but rather it increases insluin receptors' sensitivity to insulin, which will only take action when there is significant insulin in the blood, which is after meals, which is when you want this action because you also have increased glucose in the blood.
so to me, that logic makes enough sense for me to understand its euglycemic.

hope that made sense lol.
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Old 03-09-2012
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Quote:
Originally Posted by Dr.NickRiviera View Post
yea its deffo euglycemic
it doesnt increase insulin or insulin receptors (mechanisms which could yield hypoglycemia), but rather it increases insluin receptors' sensitivity to insulin, which will only take action when there is significant insulin in the blood, which is after meals, which is when you want this action because you also have increased glucose in the blood.
so to me, that logic makes enough sense for me to understand its euglycemic.

hope that made sense lol.
but main mechanism of metformin is on liver. isnt?
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Old 03-09-2012
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Quote:
Originally Posted by tyagee View Post
but main mechanism of metformin is on liver. isnt?
yea probably however exact mechanism is unknown.
decreased gluconeogenesis will favor glycolysis> lactic acidosis
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Old 03-09-2012
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it does decrease liver gluconeogenesis but i wouldnt say thats the main mechanism, id say what i wrote above (its acion on PPARs) is its main mechanism; or atleast, the most tested one.
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