Diabetes and hyperlipoproteinemenia (IV,V) - USMLE Forums
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Old 03-09-2012
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Question Diabetes and hyperlipoproteinemenia (IV,V)

Does both Diabetes type 1 and 2 cause Hyperlipo. IV and V?

I know for sure type 1 does due to insulin deficiency, but not to sure about type 2 DM.
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Old 03-09-2012
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seeing as theres no insulin deficiency in type 2, and that is what causes the hyperlipoproteinemia, i would say no, not in type 2, only in type 1.
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Old 03-09-2012
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TypeV is assoc with diabetes

insulin which is high in type2 and high in type1 exogenously activates HMG CoA Reductase, the key enzyme in cholesterol synthesis
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Old 03-09-2012
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Quote:
Originally Posted by ab_baby View Post
TypeV is assoc with diabetes

insulin which is high in type2 andhigh in type1 exogenously activates HMG CoA Reductase, the key enzyme in cholesterol synthesis

Uh.. insulin high in type 1??

This still doesn't explain why there is an increase in chylomicrons only VLDL.
Type V is both Chylo and VLDL.
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Old 03-09-2012
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I think I found the answer to my own question, but it's my theory not anything I can reference.

DM2 has HIGH insulin. This insulin usually stimulates the lipoprotein lipase which takes FAs from chylomicrons and VLDLs and stores them in the adipose as TGs.

Now when we have too much insulin this Lipoprotein lipase becomes downregulated and over time works sub-optimally. This leads to an increase in VLDL and chylos floating in the blood. BOOM... Type V hyperlip.

Seems logical to me.
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