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Old 03-10-2012
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Question Hypocalcemia and Increased Excitability

How does hypocalcemia cause increased excitability of motor neuron?...


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Old 03-10-2012
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i think it increases senstivity
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Old 03-10-2012
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calcium is membrane stabilizer.
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Quote:
Originally Posted by tyagee View Post
calcium is membrane stabilizer.
can you elaborate the mechanism pelase
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ya. i was right - u decrease ca+, u become more senstive ;p
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Quote:
Originally Posted by sfsheran View Post
ya. i was right - u decrease ca+, u become more senstive ;p
please :sorry:can you explain the MOA of increased sensitivity?
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Decreased extracellular Ca2+ (hypocalcemia) lowers the threshold potential. Thus less inward current is required to depolarize the neuron to threshold and fire an action potential.

So the mechanism you 're looking for is lowering the threshold potential.

Hope it helps...
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Old 03-10-2012
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See what StepTaker said about this here
Why Hypocalcemia causes Contraction and Hypercalcemia causes Weakness?

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Electrolytes-, Nervous-System-, Physiology-

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