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Old 03-10-2012
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Microscope Nipple lesion with intra-epidermal spread

An 83-Yr-Women comes to the physician because of an erythematous ulcerating lesion on her left nipple. A biopsy shows large, clear, mucin-filled cells with abundant cytoplasm. Intra-epidermal spread of these cells is seen.
What is the most likely?

a) Acute mastitis
b) Ductal carcinoma
c) Paget's disease
c) Intraductal papilloma
d) Invasive lobular carcinoma
e) Normal breast tissue
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Old 03-10-2012
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looks like paget's disease
-erythematous lesion of nipple
-large clear cells(paget cells)
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Old 03-10-2012
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answers - ductal carcinoma

anyone have a good explanation ? as 2 why its not pagets.
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Old 03-10-2012
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is abundant cytoplasm indicative of a carcinoma?
in which case, B is the only carcinoma listed.
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Old 03-10-2012
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on further reading, paget's disease also has ulcerating lesions & epidermal spread, so there's nothing in the stem that suggests ductal carcinoma

what is the source of this question? & is there an explanation?
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Old 03-10-2012
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Quote:
Originally Posted by Dr.NickRiviera View Post
is abundant cytoplasm indicative of a carcinoma?
in which case, B is the only carcinoma listed.
paget's disease of the breast is also a malignant disease(quote from FA: suggests underlying Carcinoma)
also, do have a look here:
http://dermaproblems.com/mammary-pagets-disease/
& here:
http://pathwiki.pbworks.com/w/page/14673877/Breast6-8
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Old 03-10-2012
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its a kaplan question, i forget the id, but its under reproductive.
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