Relationship of transferrin synthesis with ferritin stores. - USMLE Forums
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Old 03-11-2012
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RBC Relationship of transferrin synthesis with ferritin stores.

Hello,

Can anyone explain the reason behind the inverse relationship between transferrin synthesis and ferritin stores?


Any help is much appreciated. Thanks.
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Old 03-11-2012
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Ferritin is the storage form of iron. Transferrin is the binding protein of iron.(TIBC also means more or less the same as transferrin). So when the levels of ferritin are low, the body signals the liver to synthesize more of Transferrin to maintain the levels of iron in the body.

Goljan explains it really well, may be you should listen to him once.
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Old 03-11-2012
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Quote:
Originally Posted by vna.rao22 View Post
Ferritin is the storage form of iron. Transferrin is the binding protein of iron.(TIBC also means more or less the same as transferrin). So when the levels of ferritin are low, the body signals the liver to synthesize more of Transferrin to maintain the levels of iron in the body.

Goljan explains it really well, may be you should listen to him once.
When feritin levels are low that means dec iron stores transferin levls go up transferin actually transports iron and tibc is its capacity to bind iron.
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Quote:
Originally Posted by vna.rao22 View Post
Ferritin is the storage form of iron. Transferrin is the binding protein of iron.(TIBC also means more or less the same as transferrin). So when the levels of ferritin are low, the body signals the liver to synthesize more of Transferrin to maintain the levels of iron in the body.

Goljan explains it really well, may be you should listen to him once.
Can you please further explain how increasing transferrin, a binding protein for iron, helps the body maintain the levels of iron in the body. It will only increase the level of iron if there is something to bind to right? If there is a shortage of iron, how will increasing the binding protein for iron maintain the iron level?
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low ferritin levels are an indication to the body to absorb more iron from the GIT, more iron, more binding to transferrin(whose levels also increase)-- serum iron levels increase.
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vna.rao22 thank you for that explanation. I understand it now. Transferrin increases the iron level by increasing the absorption of iron from the GIT!
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