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  #1  
Old 04-16-2010
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Question Increased Glucocerebroside in Liver Biopsy?

A 3-year-old boy with mental retardation has hepatosplenomegaly. Analysis of tissue obtained on biopsy of the liver shows unusually large amounts of glucocerebroside. Which of the following enzymes is most likely to be deficient?

(A) Hormone-sensitive lipase
(B) Lipoprotein lipase
(C) Lysosomal hydrolase
(D) Sphingolipid synthase
(E) Tissue phospholipase
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Old 04-16-2010
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i think the ans is lysosomal hydrolase. the patient probably has Gauchers dx.
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Old 04-16-2010
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Idea! (C) Lysosomal hydrolase

(C) Lysosomal hydrolase
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Old 04-18-2010
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yes the answer is C

i guess this was easy?

there's this great explanation on enzyme deficiencies in the new FA (2010), with pictures and mnemonics. i have the E-book but its too huge to be shared here. Am still figuring how i can pass it to everyone here.
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Old 04-18-2010
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Smile How to share your 2010 First Aid

Quote:
Originally Posted by Seetal View Post
there's this great explanation on enzyme deficiencies in the new FA (2010), with pictures and mnemonics. i have the E-book but its too huge to be shared here. Am still figuring how i can pass it to everyone here.
One way you can share it is by breaking it up into smaller PDF files and then send them as attachments to a PM here in this website. Do not post it as an attachment to a post because the staff will immediately remove it.
How to split PDF files?
download free software from pdfsam.org and you can then split all your PDF files easily.

So were you talking about this page
Increased Glucocerebroside in Liver Biopsy?-first-aid-usmle-step-1-2010_page111.jpg
click to enlarge
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