Potassium sparing diuretics and metabolic acidosis - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-12-2012
MedicalExaminer's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 824
Threads: 66
Thanked 465 Times in 298 Posts
Reputation: 475
Drug Potassium sparing diuretics and metabolic acidosis

Its absolutely logical that spironolactone causes acidosis through its antagonising action on aldosterone receptors, but i dont get how other K sparing diuretics cause acidosis
Could anyone plz explain
__________________
Everything is possible for him who believes (MARK 9:23)
245/247/passed on 1st attempt/223/2mos Obsie /3 US LORS/visa not needed/2008 grad
Reply With Quote Quick reply to this message



  #2  
Old 03-12-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,406
Threads: 118
Thanked 647 Times in 409 Posts
Reputation: 657
Default

not sure how they would (or if they do) at the level of the tubules of the kidney.

but the hyperkalemia they cause will cause K+ to go into cells in exchange for H+ via the K+/H+ exchanger.
__________________
"inflammable means flammable!? What a country."
Reply With Quote Quick reply to this message
The above post was thanked by:
MedicalExaminer (03-12-2012)
  #3  
Old 03-12-2012
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 122
Threads: 45
Thanked 57 Times in 34 Posts
Reputation: 67
Default

Anything that causes your serum to have high K+ will causes all cells to shift K+ into the cell in exchange for H+ out of the cell through the K+/H+ ATPase.
Reply With Quote Quick reply to this message
The above post was thanked by:
MedicalExaminer (03-12-2012)
 
  #4  
Old 03-12-2012
MedicalExaminer's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 824
Threads: 66
Thanked 465 Times in 298 Posts
Reputation: 475
Default

I always thaught that it was one way mechanism acidosis-hyperkalemia
Alkalosis-hypokalemia

Thx for clarifying this
__________________
Everything is possible for him who believes (MARK 9:23)
245/247/passed on 1st attempt/223/2mos Obsie /3 US LORS/visa not needed/2008 grad
Reply With Quote Quick reply to this message
The above post was thanked by:
Dhakshi (10-30-2016)



Reply

Tags
Acid-Base-, Pharmacology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Question about anion gap in metabolic acidosis. Dry815 USMLE Step 1 Forum 2 01-21-2012 07:07 PM
metabolic acidosis/alkolosis how to tell? pshah514 USMLE Step 1 Forum 1 09-11-2011 07:02 PM
can someone please explain anion gap metabolic acidosis? DoctorB USMLE Step 1 Forum 3 03-29-2011 10:31 PM
Why Renal Tubular Acidosis is normal gap metabolic acidosis? hippocampus USMLE Step 1 Forum 5 03-11-2010 07:12 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)