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Old 03-13-2012
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ObGyn Maternal versus Gestational Diabetes effects on infant!

Is there a difference in the signs and symptoms of newborn (infant of diabetic mother) if the mother already has diabetes before pregnancy or gestational diabetes?
Does they both get caudal regression syndrome and sirenomelia?
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Old 03-13-2012
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I think it is associated with maternal diabetes (mom already had the diabetes before conception). Maternal Diabetes can cause caudal regression syndrome, transposition of the great vessels and macrocephaly.

I don't know if gestational diabetes affects fetus.
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Old 03-13-2012
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Info The concept

Gestational diabetes usually peaks mid pregnancy when the enlarging placenta and rising gestational hormones play role in initiating the insulin resistance.

Therefore, in gestational diabetes, you usually do not have high maternal blood sugars during the first trimester and as you know the critical period of organogenesis occurs during the first trimester and therefore you don't have caudal regression or other structural defects in infants of gestational diabetes mothers.

However, other metabolic effects such as infantile hypoglycemia, large for gestation, jaundice, hypocalcemia, ..etc can still be seen in both cases (maternal diabetes and maternal gestational diabetes) as these are generated later in pregnancy.

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Old 03-14-2012
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Quote:
Originally Posted by StepTaker View Post
Gestational diabetes usually peaks mid pregnancy when the enlarging placenta and rising gestational hormones play role in initiating the insulin resistance.

Therefore, in gestational diabetes, you usually do not have high maternal blood sugars during the first trimester and as you know the critical period of organogenesis occurs during the first trimester and therefore you don't have caudal regression or other structural defects in infants of gestational diabetes mothers.

However, other metabolic effects such as infantile hypoglycemia, large for gestation, jaundice, hypocalcemia, ..etc can still be seen in both cases (maternal diabetes and maternal gestational diabetes) as these are generated later in pregnancy.

-
thank you very much , I had question in NBME , it asked about mother had gestational diabetes and asked about the baby and the choices were macrosomia and sirenomelia , that was confusing a little
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