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#1
04-18-2010
 USMLE Forums Scout Steps History: 1+CK+CS Posts: 81 Threads: 59 Thanked 172 Times in 43 Posts Reputation: 182
Research Drug Half Life?

A new research drug under study has been found to have a volume of distribution of 35L and a clearance of 690 ml/min. Minute half life of this drug is closest to which of the following values?

A- 15
B- 35
C- 65
D- 105
E- 205
 The above post was thanked by: aungawa (04-18-2010)

#2
04-18-2010
 USMLE Forums Addict Steps History: 1+CK+CS Posts: 187 Threads: 4 Thanked 368 Times in 121 Posts Reputation: 398

Although USMLE is not very fond of memorizing formulas, the following one may save the day in such questions as the present one.

t1/2 = (0.7 x Vd) / Clearence

690 mL/min = 0.7 L/min approximately.

So, (0.7 x 35L) / 0.7 L/min = 35 min (choice B).
 The above post was thanked by: AkosuaBiopelo (04-18-2010), Yallah (04-18-2010)
#3
04-18-2010
 USMLE Forums Veteran Steps History: 1 + CK Posts: 234 Threads: 63 Thanked 127 Times in 63 Posts Reputation: 157

yes that is the ans. 35
#4
04-19-2010
 USMLE Forums Master Steps History: Step 1 Only Posts: 919 Threads: 134 Thanked 1,301 Times in 364 Posts Reputation: 1324

yup yup. i agree. B is the answer:

t1/2 = (0.7 x Vd) / CL

 Tags Pharmacology-, Step-1-Questions

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