Question about Second Messengers - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 03-16-2012
bunny's Avatar
Steps History: Not yet
Posts: 176
Threads: 34
Thanked 117 Times in 69 Posts
Reputation: 127
Question Question about Second Messengers

A 35-year-old female complains of excessive urination during the past four days. She has a history of bipolar disorder for which she has been treated for the past 15 years. A water restriction test is performed, and no elevation in urine osmolality is observed following the administration of desmopressin. Which of the following most likely accounts for her recent onset polyuria?

A. Inhibition of cAMP synthesis in the renal tubule
B. Inhibition of inositol trisphosphate synthesis in the renal tubule
C. Stimulation of cAMP synthesis in the renal tubule
D. Stimulation of inositol trishosphate synthesis in the renal tubule
E. Stimulation of aquaporin-2 channel insertion in the renal tubule
Reply With Quote Quick reply to this message

Old 03-16-2012
beka-CTS's Avatar
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 763
Threads: 77
Thanked 1,321 Times in 347 Posts
Reputation: 1331
Default lithium Nephropathy

A. Inhibition of cAMP synthesis in the renal tubule

ADH itself acts through Protein Kinase A -> increase Camp -> insertion of Aquaporin in the luminal Part -> increased water absorption.

The patient has history of Bipolar disoerder -> Lithium -> lithium nephropathy -> impaired Function of ADH -> decreased cAMP.
Step 1 - 244 [✔] Step 2 CK - 246 [✔] Step 2 CS [✔] Step 3 - 228 [✔] Match [EMORY SOM] YOG: 2013, 4 Months of USCE University Hospital
Reply With Quote Quick reply to this message
The above post was thanked by:
bunny (03-16-2012)


Molecular-Biology-, Step-1-Questions

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
question help: diabetic foot related question dezirablize USMLE Step 2 CK Forum 5 01-15-2015 02:42 PM
a question concerning step1 question length sfsheran USMLE Step 1 Forum 2 01-30-2012 08:29 PM
Set Question list/Different Question for each CC tbk568 USMLE Step 2 CS Forum 0 12-13-2011 01:47 AM
Second messengers for.... usmledee USMLE Step 1 Forum 6 02-12-2011 03:58 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)