Classify this hemolytic anemia? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-17-2012
bunny's Avatar
Banned
 
Steps History: Not yet
Posts: 176
Threads: 34
Thanked 117 Times in 69 Posts
Reputation: 127
RBC Classify this hemolytic anemia?

A middle age patient presents with history of tiredness, pain in his abdomen, and sexual dysfunction. Blood lab results shows a decrease serum haptoglobin, and a normocytic anemia with pancytopenia. The patient's condition is best described as

A. Intrinsic hemolytic anemia/extravascular hemolysis
B. Extrinisc hemolytic anemia/intravascular hemolysis
C. Intrinsic hemolytic anemia/intravascular hemolysis
D. Extrinisc hemolytic anemia/extravascular hemolysis
E. Positive Direct Coomb's Test/extravascular hemolysis
Reply With Quote Quick reply to this message



  #2  
Old 03-17-2012
Hitman's Avatar
USMLE Forums Master
 
Steps History: Not yet
Posts: 928
Threads: 17
Thanked 539 Times in 375 Posts
Reputation: 549
Default

Ans .....C .............
Reply With Quote Quick reply to this message
  #3  
Old 03-17-2012
Dr. Mexito's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 662
Threads: 72
Thanked 369 Times in 204 Posts
Reputation: 379
Default

Low haptoglobin... C? anemia of chronic disease?
__________________
"Disease is very old, and nothing about it has changed. It is we who change as we learn to recognize what was formerly imperceptible." JMC
Reply With Quote Quick reply to this message
 
  #4  
Old 03-17-2012
patho2012's Avatar
USMLE Forums Veteran
 
Steps History: ---
Posts: 213
Threads: 13
Thanked 119 Times in 81 Posts
Reputation: 129
Default

B..........due to drug or cancer.............but not sure about the agent..........
Reply With Quote Quick reply to this message
  #5  
Old 03-17-2012
Master shifu's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 191
Threads: 14
Thanked 87 Times in 59 Posts
Reputation: 97
Default

i would go with option (b) as decreased serum haptoglobin reflecting intravascular haemolysis and pancytopenia with normochromic anemia more likely extrinsic haemolysis
Reply With Quote Quick reply to this message
  #6  
Old 03-17-2012
Hitman's Avatar
USMLE Forums Master
 
Steps History: Not yet
Posts: 928
Threads: 17
Thanked 539 Times in 375 Posts
Reputation: 549
Default

WTF..........Hey when I solved the Qs there was also a sucrose water test in it
which lead me to PNH ....... and C as the ANS ........
Reply With Quote Quick reply to this message
  #7  
Old 03-17-2012
patho2012's Avatar
USMLE Forums Veteran
 
Steps History: ---
Posts: 213
Threads: 13
Thanked 119 Times in 81 Posts
Reputation: 129
Default

....Bunny has the final say...I was in your shoes once or twice, I know the feeling, some alteration was added just right after I had made the decision...Hope that bunny will add more Qs tomorrow...It's your chance of redemption tomorrow hit-everything-man...
Reply With Quote Quick reply to this message
  #8  
Old 03-17-2012
Hitman's Avatar
USMLE Forums Master
 
Steps History: Not yet
Posts: 928
Threads: 17
Thanked 539 Times in 375 Posts
Reputation: 549
Default

Quote:
Originally Posted by patho2012 View Post
....Bunny has the final say...I was in your shoes once or twice, I know the feeling, some alteration was added just right after I had made the decision...Hope that bunny will add more Qs tomorrow...It's your chance of redemption tomorrow hit-everything-man...

, sure ........
Reply With Quote Quick reply to this message
  #9  
Old 08-11-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 35
Threads: 14
Thanked 9 Times in 5 Posts
Reputation: 19
Default

C is correct,pancytopenia and sexual dysfunction are features of PNH.
Reply With Quote Quick reply to this message
  #10  
Old 08-11-2012
Kabutar111's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 414
Threads: 30
Thanked 87 Times in 70 Posts
Reputation: 97
Send a message via Skype™ to Kabutar111
Default

decrease serum haptoglobin------> intravascular
normo, pan ----> intrinsic ?>>
__________________
There is no shortcut to SUCCESS ,and there is no excuse for FALIURE - by Kabutar111
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #11  
Old 08-11-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 126
Threads: 6
Thanked 43 Times in 22 Posts
Reputation: 53
Default

PNH occur lysis of RBCs, neutroph and platelets due STEM CELL disease, a defect in DAF, the question doesn`t indicate any intake of drug, wich may cause aplastic anemia (cloramph, alkilating agents, methimazole)
Reply With Quote Quick reply to this message
  #12  
Old 08-15-2012
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 3
Threads: 0
Thanked 1 Time in 1 Post
Reputation: 11
Default

Quote:
Originally Posted by bunny View Post
A middle age patient presents with history of tiredness, pain in his abdomen, and sexual dysfunction. Blood lab results shows a decrease serum haptoglobin, and a normocytic anemia with pancytopenia. The patient's condition is best described as

A. Intrinsic hemolytic anemia/extravascular hemolysis
B. Extrinisc hemolytic anemia/intravascular hemolysis
C. Intrinsic hemolytic anemia/intravascular hemolysis
D. Extrinisc hemolytic anemia/extravascular hemolysis
E. Positive Direct Coomb's Test/extravascular hemolysis
B is correct answer:

Intravascular hemolysis: hemoglobinemia, hemoglobinuria, hemosiderinuria, methemoglobinemia, decreased haptoglobin and hemopexin; increased LDH

Causes of intravascular hemolysis: activation of complement on erythrocyte, physical of mechanical trauma to the RBC; soluble toxic substances

Extrinsic hemolysis: decreased haptoglobin, increased LDH; increased indirect bilirubin

Causes of extrinsic hemolytic: drugs, toxin, hypersplenism, autoimmunine (cold agglutinin), microangiopathic (DIC, TTP, HUS)
Reply With Quote Quick reply to this message



Reply

Tags
Hematology-, Pathology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
level of haptoglobin in hemolytic anemia tyagee USMLE Step 2 CK Forum 2 07-26-2014 01:14 AM
Confusing Hemolytic Anemia tyagee USMLE Step 2 CK Forum 15 11-27-2012 03:03 PM
why there is hemolytic anemia with acanthocytes in vitamin e deficiency yasirsattar75 USMLE Step 1 Forum 1 06-06-2011 04:57 AM
Hemolytic anemia & sulfas bebix USMLE Step 1 Forum 12 05-21-2011 01:59 PM
Which enzyme deficiency causing this hemolytic anemia? sam01 USMLE Step 1 Forum 8 04-14-2010 04:17 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)