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  #1  
Old 03-17-2012
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RBC Peripheral Blood Smear after Cardiovascular Surgery!

A peripheral blood smear is performed in a 60 years old patient with past cardiovascular surgery history due to complications of a pharyngeal infection. According to the image below, which of the following options best explain the findings in his blood smear?

Peripheral Blood Smear after Cardiovascular Surgery!-954354-954356-688.jpg
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a. Liver disease
b. Lead poisoning
c. enzyme deficiency
d. vitamin deficiency
e. accumulation of metabolic product
f. traumatic hemolysis
g. hypoxic stress phenomenon
h. autoimmune disorder
i. bone marrow infiltration disorder
j. cytoskeleton abnormalities
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Old 03-17-2012
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Default Liver Disease

Acanthocytes are asscociated with Liver Disease
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Old 03-17-2012
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F:eff...eff...
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Old 03-17-2012
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i'd go with (f) too. It was my first intention when i read the stem (heart surgery is classic for that) the picture distracted me a bit (a) but i can't get rid of the feeling that there should be more acanthos in the picture for (a)
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Old 03-17-2012
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Quote:
Originally Posted by patho2012 View Post
F:eff...eff...
Yeap... eff

Equinocytes (aka burr cells) = mechanical trauma.

A) Would be acantocytes, and they are seen in abetalipoproteinemia.

They look very similar, although they are due to different pathology.
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Peripheral Blood Smear after Cardiovascular Surgery!-954354-954356-688.jpg   Peripheral Blood Smear after Cardiovascular Surgery!-954354-954356-686.jpg  
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Old 03-17-2012
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how to diff. b\w acanthocytes and echinocytes in pbf?
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Old 03-18-2012
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Quote:
Originally Posted by tyagee View Post
how to diff. b\w acanthocytes and echinocytes in pbf?
actually acanthocytes are more thorny and their thorns are sharly pointed just like the rose thorns.

This type of red cell abnormality is associated with a variety of inherited and acquired disorders including the following:-
1. Abetalipoproteinemia
2. Chorea-acanthocytosis
3. McLeod phenotype hereditary spherocytosis with a beta-spectrin deficiency
4. Liver disorders:- alcoholic cirrhosis,
5. Renal disorders : uraemia
6. vitamin E deficiency
7. anorexia nervosa, malnutrition


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Old 03-18-2012
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Quote:
Originally Posted by tyagee View Post
how to diff. b\w acanthocytes and echinocytes in pbf?
Think of Equinocytes as if you were looking a lot of crenated erythrocytes. Plus, the cell membrane is more regular (In acanthocytes is super irregular). Also, think of them if you see that the question has something to do with mechanical trauma.

In acanthocytes, patho2012 has already gave more details about it.
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Old 05-18-2012
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Default summary table of RBC morphologic abnormalities

http://www.pathology.vcu.edu/educati...cabntable.html
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Old 06-26-2012
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e. accumulation of metabolic product - uremia - burr cells also called echinocytes
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Old 12-31-2013
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If you make up your mind to go abroad for this surgery, then I can suggest you one more good hospital i.e. Justsavelives clinic, which also has an experienced team of surgeons to perform liver surgery. Hope this information will be of help for you.
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