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Old 03-17-2012
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RBC Why Lead poisoning lead to Iron overload

Hello everyone! Does anyone know how and why lead poisoning causes Iron overload?

Thanks in advance!
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Old 03-18-2012
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sorry!! I couldn't get it actually......as far as i know that lead poisoning interfere with incorporation Fe into heme by inhibiting 2 enzymes i.e. Aminolevulinic acid dehydratase and ferroketolase.......thereby leading to the devolopment of hypochromic anemia........or haemolytic type which is caused by inhibition of red blood cell membrane enzymes leading to accumulation of denatured RNA.....
But iron overload is far way to devolop as hypochromic anemia/haemolysis may result it by increasing absorption probably and you know that Fe is one kind of demon that once enters in the body is hard to get rid of it easily.
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Old 03-18-2012
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Because in lead poisoning, the iron is not being used to make heme because of the enzymatic failure, so it starts to deposit in body.this is what I think of as explanation.corrections appreciated.
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Old 03-18-2012
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sideroblastic anemia
iron isnt being incorporated into the heme so it accumulates in the mitochondria and hence, ringed sideroblasts.
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