Kallmann's syndrome and normal LH and Testosterone! - USMLE Forums
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Old 03-18-2012
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Question Kallmann's syndrome and normal LH and Testosterone!

Why are serum luteinizing hormone and testosterone levels normal in many cases of Kallmanns?

When GnRH is low/absent, shouldn't LH and FSH would be low too?
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Old 03-18-2012
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According to Goljan the lab findings should be a decreased FSH and LH.

What source do you have where its telling you its normal? A question bank?
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Old 03-18-2012
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Question:
A 15 year old is concerned about the size of his penis. He says his penis is too short and is teased about this at the gym. On examination he is noted to have delayed sexual development. He is also found to have a lack of normal smell. Investigations reveal a gonadotropin deficiency, although the serum luteinizing hormone and testosterone levels are normal. The most likely diagnosis is
a) testicular dysgenesis
b) Kallmann's syndrome
c) congenital adrenal hyperplasia
d) constitutional delay
e) craniopharyngioma


This was a question from Medical MCQ's, the answer was obviously B. I also ran into a similar question on UW quite a while back, but forgot the reason.
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Old 03-18-2012
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Quote:
Originally Posted by slowpoke View Post
Question:
A 15 year old is concerned about the size of his penis. He says his penis is too short and is teased about this at the gym. On examination he is noted to have delayed sexual development. He is also found tohave a lack of normal smell. Investigations reveal a gonadotropin deficiency, although the serum luteinizing hormone and testosterone levels are normal. The most likely diagnosis is
a) testicular dysgenesis
b) Kallmann's syndrome
c) congenital adrenal hyperplasia
d) constitutional delay
e) craniopharyngioma


This was a question from Medical MCQ's, the answer was obviously B. I also ran into a similar question on UW quite a while back, but forgot the reason.
maybe being pre-pubertal has something to do with it? i duno.
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