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Old 03-20-2012
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Drug Drug to treat hyperacute kidney rejection!

Patient requires a kidney ransplant. After transplant the patient suddenly develops a reaction, the surgeon, clarifies to the residents that this is a hyperacute rejection reaction. the surgeon then ask his residents what is the best drug of choice to immunosupress this patient. after the intravenous adminstration of the drug the patient after 45 mins starts to develop fever, hypotension, and later pulmonary edema. what was the mechanism of action of the drug inserted into the patient?

a) monoclonal ab with high affinity for IL-2 receptor
b) monoconal ab that binds CD3 receptor
c) antimetabolite precursor of 6 mercaptopurine
d) binds to mTOR inhibiting t cell proliferation
e) binds to cyclophilins
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Old 03-20-2012
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E)binds to cyclophilins (Cyclosporine - can cause nephrotoxicity as a Side effect)
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Old 03-20-2012
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Ans B ......

Muromonab causes Hypersensitivity reaction .......
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Quote:
Originally Posted by Hitman View Post
Ans B ......

Muromonab causes Hypersensitivity reaction .......
Ah, that's true but the question says the patient has a reaction after 45 mins. Is that hyperacute reaction ? ... With his T cells inhibited he will not have any T cell, B cell or Plasma cell (Antibody) Reaction ..right ? How can it cause a hypersensitivity reaction then ?
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Quote:
Originally Posted by Hope2Pass View Post
Ah, that's true but the question says the patient has a reaction after 45 mins. Is that hyperacute reaction ? ... With his T cells inhibited he will not have any T cell, B cell or Plasma cell (Antibody) Reaction ..right ? How can it cause a hypersensitivity reaction then ?
Well hypersensitivity reactions to drugs are due to preformed Abs , the Qs doesnot say about the patient being treated with any drug before ...

his sudden onset of symptoms after the drug with fever and hypotension indicate hypersensitivity to the drug ...... yes the drug will itself inhibit the Tcells but the Ab to drug are already present before hand ...the 45 mins time duration is may be the time needed to develop the response since it is give the first time ....... I find the Qs is asking about a drug cause Hypersensitivity reaction and this one fits .... becoz rest all can be used for transplant ..
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